Results 41 to 50 of about 22,691 (239)
Nrf2 inhibition suppresses propofol-induced cytoprotection.
, 2018 A-D: Effect of Nrf2, HO-1, Nqo-1 or scramble siRNA on propofol-induced cytoprotection, after at 24 h after treatment with H2O2. Cytotoxicity was measured using an LDH assay. n = 3. The data are expressed as mean ± SEM. *P P < 0.01. N.S., not significant.
Kentaro Oh-hashi (2179958) +10 more
core +1 more source
Selenium in Oncology: From Chemistry to Clinics
Molecules, 2009 The essential trace element selenium, which is a crucial cofactor in the most important endogenous antioxidative systems of the human body, is attracting more and more the attention of both laypersons and expert groups. The interest of oncologists mainly
Oliver Micke +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu +10 more
wiley +1 more source
Mechanisms of ischemia and reperfusion-induced cytoprotection in canine gracilis muscle [PDF]
, 2000 grantor: University of TorontoIschemia and reperfusion are known for their deleterious effects. Recent evidence, however, indicates that they may also produce a beneficial consequence.
Liauw, Shinta
core +2 more sources
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
, 2017 Chemical-induced nephrotoxicity is a major cause of acute kidney injury. My dissertation reveals that all-trans-retinoic acid (ATRA) affords cytoprotection against renal cell injury.
Sapiro, Jessica M.
core +5 more sources
Phloretin cytoprotection and toxicity
Chemico-Biological Interactions, 2018 Phloretin (Phl) is a dihydrochalcone flavonoid with significant cytoprotective properties; e.g., free radical trapping, electrophile scavenging. Based on this, it has been suggested that Phl might be useful in the treatment of pathogenic processes and prevention of drug toxicities.
Brian C. Geohagen +4 more
openaire +3 more sources
NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
openaire +2 more sources
Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
wiley +1 more source
, 2020 We reviewed again the significance of the stable gastric pentadecapeptide BPC 157 as a likely mediator of Robert’s stomach cytoprotection/adaptive cytoprotection and organoprotection and as novel mediator of Selye’s stress coping response to reestablish ...
Ante Tvrdeic +11 more
core +1 more source