Results 1 to 10 of about 44,634 (185)

Bradykinin-bradykinin 2 receptor and oxidative stress [PDF]

Annals of Medicine
Introduction Bradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic ...
Jun Zhao, Zhuanping Wang, Xuetao Wang, Fangjun Yang, Huirong Xi, Jiantao Wen, Wenjing Zhang, Xiaoming Qiu   +7 more
doaj   +2 more sources

Systemic role of orexin A, substance P, bradykinin, and DABK in severe COVID-19 and 2.5-yr follow-ups: an observational study [PDF]

BJA Open
Background: Orexin A regulates sleep–wake cycles, arousal, and energy homeostasis, linking it to the renin–angiotensin system and substance P. Dysfunction in these pathways occurs in acute and long-term COVID-19, including post-COVID syndrome.
Ulrike Heinicke, Steven R. Talbot, Filippos Thanasis, Elisabeth H. Adam, Andreas von Knethen, Andrea U. Steinbicker, Sebastian Zinn, Kai Zacharowski, Armin N. Flinspach   +8 more
doaj   +2 more sources

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension [PDF]

Dose-Response, 2017
In hypertension, the combination therapy is frequently used to obtain a better therapeutic effect and reduce adverse effects. One effective combination is with inhibitors and β-blockers of renin–angiotensin system.
Diego Lezama-Martínez MD, Ignacio Valencia-Hernández PhD, Jazmin Flores-Monroy PhD, Luisa Martínez-Aguilar PhD   +3 more
doaj   +2 more sources

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Nature Communications, 2023
An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo   +14 more
doaj   +1 more source

The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19

Frontiers in Physiology, 2022
Patients infected by the SARS-CoV-2 virus are commonly diagnosed with threatening liver conditions associated with drug-induced therapies and systemic viral action.
Gabriel Moreira de M Mendes, Gabriel Moreira de M Mendes, Israel Júnior Borges Do Nascimento, Israel Júnior Borges Do Nascimento, Paulo HS. Marazzi-Diniz, Izabela B. Da Silveira, Izabela B. Da Silveira, Matheus F. Itaborahy, Matheus F. Itaborahy, Luiz E. Viana, Luiz E. Viana, Filipe A. Silva, Monique F Santana, Rebecca AA. Pinto, Bruna G. Dutra, Marcus Vinicius G. Lacerda, Stanley A. Araujo, David Wanderley, Paula VT. Vidigal, Paulo HC Diniz, Thiago Verano-Braga, Robson AS. Santos, M Fatima Leite   +22 more
doaj   +1 more source

Bradykinin-induced angioedema in the emergency department

International Journal of Emergency Medicine, 2022
Background Acute airway angioedema commonly occurs through two distinct mechanisms: histamine- and bradykinin-dependent. Although they respond to distinct treatments, these two potentially life-threatening states present similarly.
Jacques Hébert, Jean-Nicolas Boursiquot, Hugo Chapdelaine, Benoit Laramée, Marylin Desjardins, Rémi Gagnon, Nancy Payette, Oleksandra Lepeshkina, Matthieu Vincent   +8 more
doaj   +1 more source

Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. [PDF]

PLoS ONE, 2012
Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke.
Antonio H Martins, Janaina M Alves, Dinely Perez, Marimeé Carrasco, Wilmarie Torres-Rivera, Vesna A Eterović, Pedro A Ferchmin, Henning Ulrich   +7 more
doaj   +1 more source

Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients

Neurobiology of Disease, 2020
Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits, brain atrophy, vascular dysfunction, and chronic inflammation.
Pradeep K. Singh, Zu-Lin Chen, Dhiman Ghosh, Sidney Strickland, Erin H. Norris   +4 more
doaj   +1 more source

Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19

Scientific Reports, 2021
The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
doaj   +1 more source

Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19

Mediators of Inflammation, 2022
The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum, Mohammad Shahid Iqbal, Sadia Sultan, Raghad Ali Alhuthali, Deena Ismail Alshubaili, Raghad Salah Sayyam, Lama Mohammed Abyad, Ahmed H. Qasem, Ahmad F. Arbaeen   +8 more
doaj   +1 more source