Pakistan Armed Forces Medical Journal, 2020 Objective: To study the relaxant effect of ropivacaine against acetylcholine and bradykinin induced airway contraction of isolated tracheal tissue of guinea pig in vitro. Study Design: Laboratory based experimental study.
Fatima Qasim Malik +2 more
doaj +1 more source
Nature Communications, 2023 An important role for liver in the regulation of adipose tissue thermogenesis upon cold exposure has been suggested; however, the underlying mechanisms remain incompletely defined.
Fei Xiao +14 more
doaj +1 more source
The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19
Frontiers in Physiology, 2022 Patients infected by the SARS-CoV-2 virus are commonly diagnosed with threatening liver conditions associated with drug-induced therapies and systemic viral action.
Gabriel Moreira de M Mendes +22 more
doaj +1 more source
Bradykinin-induced angioedema in the emergency department
International Journal of Emergency Medicine, 2022 Background Acute airway angioedema commonly occurs through two distinct mechanisms: histamine- and bradykinin-dependent. Although they respond to distinct treatments, these two potentially life-threatening states present similarly.
Jacques Hébert +8 more
doaj +1 more source
Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. [PDF]
PLoS ONE, 2012 Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke.
Antonio H Martins +7 more
doaj +1 more source
Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer's patients
Neurobiology of Disease, 2020 Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits, brain atrophy, vascular dysfunction, and chronic inflammation.
Pradeep K. Singh +4 more
doaj +1 more source
Sensitive mass spectrometric determination of kinin-kallikrein system peptides in light of COVID-19
Scientific Reports, 2021 The outbreak of COVID-19 has raised interest in the kinin–kallikrein system. Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known
Tanja Gangnus, Bjoern B. Burckhardt
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SP-Sephadex equilibrium chromatography of bradykinin and related peptides: Application to trypsin-treated human plasma [PDF]
, 1977 An analytical method is deseribed for the separation of bradykinin, Lys-bradykinin, and Met-Lys-bradykinin by equilibrium chromatography on SP-Sephadex C-25 eluted in 0.02 Tris-HCl buffer, pH 8.10, 0.12 NaCl.
Camargo, Antonio C. M. +4 more
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Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID-19
Mediators of Inflammation, 2022 The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care.
Aisha Tabassum +8 more
doaj +1 more source
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
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