Results 11 to 20 of about 44,634 (185)

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

Different Prostanoids Are Involved in Bradykinin-Induced Endothelium-Dependent and -Independent Vasoconstriction in Rat Mesenteric Resistance Arteries

Journal of Pharmacological Sciences, 2004
Mechanisms underlying bradykinin-induced vasoconstriction were investigated in rat perfused mesenteric vascular beds with active tone. In preparations with intact endothelium, bolus injections of bradykinin (1 to 1,000 pmol) dose-dependently produced ...
Hideki Nawa, Yuji Kurosaki, Hiromu Kawasaki   +2 more
doaj   +1 more source

The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth

Frontiers in Endocrinology, 2022
BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to ...
Xiao-tian Ni, Wang-sheng Wang, Wang-sheng Wang, Yun Liu, Yi-kai Lin, Yi-kai Lin, Fan Zhang, Fan Zhang, Wen-jia Lei, Wen-jia Lei, Li-jun Ling, Fan Pan, Fan Pan, Ya-nan Zhu, Ya-nan Zhu, Meng-die Li, Meng-die Li, Tao Duan, Ming Liu, Kang Sun, Kang Sun   +20 more
doaj   +1 more source

Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction [PDF]

The Ukrainian Biochemical Journal, 2017
Biochemical properties of 3-substituted 1,4-benzodiazepine determined by the characteristics of their chemical structure. Influence of 3-substituted 1,4-benzodiazepin-2-ones on maximal normalized rate and amplitudes of isometric smooth muscle contraction
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, E. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

Bradykinin receptors in intestinal smooth muscles and their post-receptor events related to calcium

Mediators of Inflammation, 1993
The effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events.
Yusuf Öztürk, V. Melih Altan, Nuray Yıdızoğlu-Arı, Orhan Altınkurt   +3 more
doaj   +1 more source

Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Background/Aims: Bradykinin has been shown to exert a variety of protective effects against vascular injury, and to reduce the levels of several factors involved in the coagulation cascade.
Ruolan Dong, Wenshu Chen, Wenjing Feng, Congying Xia, Danli Hu, Yanjun Zhang, Yan Yang, Dao Wen Wang, Xizhen Xu, Ling Tu   +9 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain: Lessons From Studies on Kininogen-Deficient Rats

Journal of Pharmacological Sciences, 2003
: Roles for the kallikrein-kinin system in inflammation have been investigated extensively, and many reviews on this topic have been published during the 50 years since the discovery of bradykinin in 1949. Recent progress in the field has been remarkable
Akinori Ueno, Sachiko Oh-ishi
doaj   +1 more source

Molecular Features of Non-Selective Small Molecule Antagonists of the Bradykinin Receptors

Pharmaceuticals, 2020
Angiotensin converting enzyme 2 (ACE2) downregulation is a key negative factor for the severity of lung edema and acute lung failure observed in patients infected with SARS-CoV-2. ACE2 downregulation affects the levels of diverse peptide mediators of the
Bahareh Rasaeifar, Patricia Gomez-Gutierrez, Juan J. Perez   +2 more
doaj   +1 more source

The Pathophysiology of Hereditary Angioedema

World Allergy Organization Journal, 2010
Hereditary angioedema (HAE) causes recurrent episodes of angioedema that may be very severe and are frequently associated with significant morbidity and even mortality. Understanding the pathophysiology of this disease is crucial for proper diagnosis and
Bruce L Zuraw, MD
doaj   +1 more source