Results 41 to 50 of about 44,634 (185)

Angiotensin-converting enzyme (ACE) I/D and bradykinin B2 receptor T/C genes polymorphism in patients with ACE inhibitors-related cough

Egyptian Journal of Medical Human Genetics, 2018
Background: Angiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy.
Mohammad Saifur Rohman, Jonny Karunia Fajar, Bagus Hery Kuncahyo, Lowry Yunita, Erdo Puncak Sidarta, Putu Nina Belinda Saka, Teuku Heriansyah, Nashi Widodo   +7 more
doaj   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Bradykinin increases resensitization of purinergic receptor signaling in glioma cells

Cancer Cell International, 2010
Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C, Beltran-Parrazal Luis, López-Valdés Héctor E, Charles Andrew C   +3 more
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Pharmacological Effects of a Novel Bradykinin-Related Peptide (RR-18) from the Skin Secretion of the Hejiang Frog (Ordorrana hejiangensis) on Smooth Muscle

Biomedicines, 2020
Bradykinin (BK) and bradykinin-related peptides (BRPs), which were identified from a diversity of amphibian skin secretions, exerted contractile and relaxing effects on non-vascular and vascular smooth muscle, respectively.
Xiaowei Zhou, Jie Xu, Ruimin Zhong, Chengbang Ma, Mei Zhou, Zhijian Cao, Xinping Xi, Chris Shaw, Tianbao Chen, Lei Wang, Hang Fai Kwok   +10 more
doaj   +1 more source

Bradykinin inhibits oxidative stress-induced cardiomyocytes senescence via regulating redox state. [PDF]

PLoS ONE, 2013
BACKGROUND: Cell senescence is central to a large body of age related pathology, and accordingly, cardiomyocytes senescence is involved in many age related cardiovascular diseases.
Ruolan Dong, Xizhen Xu, Geng Li, Wenjing Feng, Gang Zhao, Junjie Zhao, Dao Wen Wang, Ling Tu   +7 more
doaj   +1 more source

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre‐Filled Pen Versus Pre‐Filled Syringe in Healthy Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Garadacimab is a novel, fully human, anti‐activated factor XII monoclonal antibody approved for long‐term prophylaxis of patients with hereditary angioedema. This open‐label, parallel‐group, Phase 1, single‐center, bridging study in healthy adults (18–55 years of age) characterized the pharmacokinetics and safety of a single 200 mg ...
Fiona Glassman, John‐Philip Lawo, Mihai Alexandru Bica, Anthony Roberts, David Kormann, Ligia Chialda, Soeren Miethke, Iwona Dziadowiec, Stephen Caltabiano, Thomas Puchalski   +9 more
wiley   +1 more source

Hereditary angioedema as a cause of recurrent abdominal pain in a pediatric patient with Crohn's disease

JPGN Reports, EarlyView.
Abstract Hereditary angioedema (HAE) is a rare genetic condition caused by deficient or dysfunctional C1 inhibitor protein (C1INH) resulting in episodic angioedema of the skin, upper airway, and gastrointestinal tract. HAE most often presents within the first two decades of life and may cause severe abdominal pain, nausea, diarrhea, and emesis, making ...
Stephanie L. Rager, Paula J. Busse, Joesph A. Picoraro   +2 more
wiley   +1 more source

Effect of 3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine-2-ones on the bradykinin-induced smooth muscle contraction

Regulatory Mechanisms in Biosystems, 2017
Damage to tissue, inflammation and disruption of normal functioning of organs are often accompanied by pain. In pain perceptions, the kinin-kallikrein system with bradykinin as mediator is very important.
P. A. Virych, O. V. Shelyuk, T. A. Kabanova, O. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati   +6 more
doaj   +1 more source

Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency

TH Open, 2020
Angiotensin-converting enzyme (ACE) inhibitors are extensively prescribed to treat patients with hypertension, congestive heart failure, and diabetic nephropathy.
Swapan K. Dasgupta, Stefanie Rivera, Perumal Thiagarajan   +2 more
doaj   +1 more source