Results 61 to 70 of about 74,387 (246)

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Intra-pancreatic release of bradykinin during the course experimental pancreatitis in rat

Mediators of Inflammation, 1996
Kallikrein/Kininogn activation is an important pathophysiological event in acute pancreatitis, leading to microcirculatory changes within the gland. Hitherto, only indirect measurements of pancreatic bradykinin formation have been performed, monitoring ...
P. Jönsson, K. Ohlsson
doaj   +1 more source

A neutrophil-dependent pathway for the generation of a neutral peptide mediator: partial characterization of components and control by alpha-1-antitrypsin. [PDF]

, 1974
A biologically active neutral peptide mediator is cleaved from a plasma protein substrate by an alpha-1-antitrypsin-inhibitable serine protease apparently residing on the membrane of the human neutrophil. The peptide mediator has an approximate mol wt of
Austen, KF, Goetzl, EJ, Wintroub, BU
core  

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source

Natural bradykinin antagonists [PDF]

Memórias do Instituto Oswaldo Cruz, 1991
Bradykinin (BK) a nonapeptide generated in plasma during tissue injury, is involved in many physiological and pathological states. Kinin actions are mediated by specific membrane receptors and involve a complex signal transducer and also second messenger mechanisms.
Calixto, João B., Yunes, Rosendo A.
openaire   +4 more sources

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Bradykinin increases resensitization of purinergic receptor signaling in glioma cells

Cancer Cell International, 2010
Background Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain tumors and may correlate with ...
Brennan Kevin C, Beltran-Parrazal Luis, López-Valdés Héctor E, Charles Andrew C   +3 more
doaj   +1 more source

Buck Wheat: Nutritional, Bioactive Characteristics, Health Benefits, and Side Effects

Future Postharvest and Food, EarlyView.
ABSTRACT Micronutrient deficits have resulted from an over‐reliance on a small number of cereal crops for food security. The agricultural sector faces severe sustainability issues due to the rapid growth of the world's population and sudden climatic changes.
Momina Farooq, Sajad Ahmad Mir, Zahida Naseem   +2 more
wiley   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Pharmacological Effects of a Novel Bradykinin-Related Peptide (RR-18) from the Skin Secretion of the Hejiang Frog (Ordorrana hejiangensis) on Smooth Muscle

Biomedicines, 2020
Bradykinin (BK) and bradykinin-related peptides (BRPs), which were identified from a diversity of amphibian skin secretions, exerted contractile and relaxing effects on non-vascular and vascular smooth muscle, respectively.
Xiaowei Zhou, Jie Xu, Ruimin Zhong, Chengbang Ma, Mei Zhou, Zhijian Cao, Xinping Xi, Chris Shaw, Tianbao Chen, Lei Wang, Hang Fai Kwok   +10 more
doaj   +1 more source