Results 71 to 80 of about 50,349 (192)
British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley +1 more source
Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy
Frontiers in Medicine, 2018 Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied.
Carlos C. Barros +21 more
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Lisinopril-Induced Angioedema in a Patient with Plasma Prekallikrein Deficiency
TH Open, 2020 Angiotensin-converting enzyme (ACE) inhibitors are extensively prescribed to treat patients with hypertension, congestive heart failure, and diabetic nephropathy.
Swapan K. Dasgupta +2 more
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CD93—An emerging vascular target in cancer therapy
British Journal of Pharmacology, EarlyView.Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira +3 more
wiley +1 more source
The Expression of Neuropeptides in Pulpitis: A Systematic Review and Meta‐Analysis
International Endodontic Journal, EarlyView.ABSTRACT Background Neuropeptides play key roles in the inflammatory, nociceptive and reparative processes of the dental pulp. Their upregulation has been frequently observed in inflamed pulps, suggesting potential diagnostic value supporting a role for neurogenic inflammation in symptomatic irreversible pulpitis.
N. Watson +3 more
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, 2021 Kinins, such as bradykinin and kallidin, are peptides generated from kininogen precursor proteins by the action of kallikreins. Plasma and tissue kallikrein are responsible for their synthesis in blood and tissues, respectively.
Sara Maghsodi +5 more
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Management of chronic urticaria: Current status and future prospect
Journal of the European Academy of Dermatology and Venereology, EarlyView.Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman +15 more
wiley +1 more source
Cell Reports, 2019 Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
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Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
, 2017 Prostate cancer is the most commonly diagnosed malignancy in men and shows a tendency for metastasis to distant organs. Angiogenesis is required for metastasis.
戴槐青 +1 more
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