Results 81 to 90 of about 50,349 (192)

Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
ATP has broad functions as an autocrine/paracrine molecule. The mode of ATP release and its intracellular source, however, are little understood. Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the ...
Yumei Zhao, Keisuke Migita, Chiemi Sato, Sadaharu Usune, Takahiro Iwamoto, Takeshi Katsuragi   +5 more
doaj   +1 more source

Study of noscapine effects on rat hind paw inflammation induced by bradykinin and histamine

Journal of Medicinal Plants, 2006
Background: Noscapine is an isoquline alkaloid from opium with antitussive effect. Our previous study indicated that noscapine is non-competitive inhibitor of bradykinin. Objective: Since bradykinin and histamine contribute in inflammatory processes, the
N Shiri, M Shafiei, SH Pashaeirad, M Mahmoudian   +3 more
doaj  

Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.

PLoS ONE, 2017
ObjectiveTo examine the association of bradykinin and related peptides with the development of diabetic nephropathy lesions in 243 participants with type 1 diabetes (T1D) from the Renin-Angiotensin System Study who, at baseline, were normoalbuminuric ...
Kevin M Wheelock, Jian Cai, Helen C Looker, Michael L Merchant, Robert G Nelson, Gudeta D Fufaa, E Jennifer Weil, Harold I Feldman, Ramachandran S Vasan, Paul L Kimmel, Brad H Rovin, Michael Mauer, Jon B Klein, CKD Biomarkers Consortium   +13 more
doaj   +1 more source

The acute and chronic effects of local aerobic exercise on cardiovascular physiology

Experimental Physiology, EarlyView.
Abstract Exercise training has beneficial effects for primary and secondary prevention of cardiovascular disease (CVD). Effects of exercise training have typically been studied in the form of whole‐body exercise training, partly driven by the assumption that larger effects of exercise training can be achieved by involving more and larger muscle groups.
Myrthe P. F. van de Ven, Janneke Vloet, Daphne Merkus, Dick H. J. Thijssen   +3 more
wiley   +1 more source

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

Genetic alterations in epilepsy: the cases of Unverricht- Lundborg disease, Fragile X and B1 null mutation [PDF]

, 2009
Genetic mechanisms are estimated to underlie about 40% of epilepsies and may present with different manifestations and syndromes. In this thesis, three different cases of genetic implications in epilepsy have been studied: Unverricht-Lundborg disease ...
Buzzi, Andrea
core  

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Increased Expression of mRNA for B1 and B2 Bradykinin Receptors in the Skin of Adjuvant Inoculated Rats

, 2002
2002-12Bradykinin is the most established endogenous algesic substance. It has two receptors subtypes, B1 and B2, which are classified based on their pharmacological properties. It is generally accepted that the B2 receptor (B2R) is normally expressed in
KOZAKI, Yasuko, MIZUMURA, Kazue, UENO, Tomoyuki   +2 more
core   +1 more source

Reducing Brain Edema Using Berotralstat, an Inhibitor of Bradykinin, Repurposed as Treatment Adjunct in Glioblastoma

Neuroglia
Glioblastomas synthesize, bear receptors for, and respond to bradykinin, triggering migration and proliferation. Since centrifugal migration into uninvolved surrounding brain tissue occurs early in the course of glioblastoma, this attribute defeats local
Richard E. Kast
doaj   +1 more source

Bradykinin and adenosine receptors mediate desflurane induced postconditioning in human myocardium: role of reactive oxygen species

BMC Anesthesiology, 2010
Background Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in ...
Gérard Jean-Louis, Massetti Massimo, Babatasi Gérard, Ivascau Calin, Rouet René, Buléon Clément, Lemoine Sandrine, Hanouz Jean-Luc   +7 more
doaj   +1 more source