Results 101 to 110 of about 74,387 (246)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Reducing Brain Edema Using Berotralstat, an Inhibitor of Bradykinin, Repurposed as Treatment Adjunct in Glioblastoma

Neuroglia
Glioblastomas synthesize, bear receptors for, and respond to bradykinin, triggering migration and proliferation. Since centrifugal migration into uninvolved surrounding brain tissue occurs early in the course of glioblastoma, this attribute defeats local
Richard E. Kast
doaj   +1 more source

elPBN neurons regulate rVLM activity through elPBN-rVLM projections during activation of cardiac sympathetic afferent nerves. [PDF]

, 2016
The external lateral parabrachial nucleus (elPBN) within the pons and rostral ventrolateral medulla (rVLM) contributes to central processing of excitatory cardiovascular reflexes during stimulation of cardiac sympathetic afferent nerves (CSAN).
Fu, Liang-Wu, Guo, Zhi-Ling, Longhurst, John C, Tjen-A-Looi, Stephanie C   +3 more
core   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Bradykinin and adenosine receptors mediate desflurane induced postconditioning in human myocardium: role of reactive oxygen species

BMC Anesthesiology, 2010
Background Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in ...
Gérard Jean-Louis, Massetti Massimo, Babatasi Gérard, Ivascau Calin, Rouet René, Buléon Clément, Lemoine Sandrine, Hanouz Jean-Luc   +7 more
doaj   +1 more source

Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways [PDF]

, 2006
Many sensations of pain are evoked by mechanical stimuli, and in inflammatory conditions, sensitivity to such stimuli is commonly increased. Here we used cultured sensory neurons as a model of the peripheral terminal to investigate the effects of ...
DI CASTRO, MARIA AMALIA, LIAM J. DREW, JOHN N. WOOD, AND PAOLO CESARE   +3 more
core   +1 more source

Berotralstat and Health‐Related Quality of Life in Hereditary Angioedema: Pooled Analysis of the APeX‐2 and APeX‐J Trials

Clinical &Experimental Allergy, EarlyView.
Pooled analysis of the phase 3 APeX‐2 and APeX‐J trials evaluated the impact of berotralstat 150 mg on health‐related quality of life in patients with hereditary angioedema using the Angioedema Quality of Life (AE‐QoL) questionnaire. Berotralstat significantly improved AE‐QoL total and domain scores for daily functioning and fears/shame versus placebo ...
Teresa Caballero, Sorena Kiani‐Alikhan, Douglas T. Johnston, Aolin Wang, Lorena Lopez‐Gonzalez, Zheng‐Yi Zhou, Fan Yang, Hannah H. Kim, Sandra Nestler‐Parr, Dianne Tomita, Patrick Gillard, Tamar Kinaciyan   +11 more
wiley   +1 more source

Serping1 associated with α-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson’s disease mice

Scientific Reports
Patients with Parkinson’s disease (PD) have gastrointestinal motility disorders, which are common non-motor symptoms. However, the reasons for these motility disorders remain unclear. Increased alpha-synuclein (α-syn) is considered an important factor in
Min Hyung Seo, Soo-Hwan Kim, Sujung Yeo
doaj   +1 more source

Bradykinin-bradykinin 2 receptor and oxidative stress

Annals of Medicine
Introduction Bradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic ...
Jun Zhao, Zhuanping Wang, Xuetao Wang, Fangjun Yang, Huirong Xi, Jiantao Wen, Wenjing Zhang, Xiaoming Qiu   +7 more
doaj   +1 more source

The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]

, 1964
1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
core   +1 more source