Results 111 to 120 of about 50,349 (192)

A Cohort Study on Incidence and Factors Associated With Adverse Drug Reactions of Enalapril in Lusaka, Zambia

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed but are associated with adverse drug reactions (ADR), including angioedema, which is typically reported in 0.1%–0.7%. Data from sub‐Saharan Africa are limited. This study aimed to estimate the incidence and risk factors of enalapril‐associated ADRs in a Zambian cohort, with
Ntemena Yikon'a, Ngosa Mumba, Sarah Pedretti, Helen Hoenck, Jonathan Peter, Owen Ngalamika   +5 more
wiley   +1 more source

Innovative Dose–Response Assessment of the Metaboreflex With Indirect Control of Intramuscular Metabolic Perturbation in Humans

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim We aimed to evaluate an innovative dose–response approach to assess the metaboreflex with control of intramuscular metabolic perturbation (concept of metaboreflex gain). We also investigated potential sex differences in the metaboreflex using this new approach.
Nabil Kouzkouz, Joris Mallard, Elyse Hucteau, Roland Schott, Xavier Pivot, Guillaume P. Ducrocq, Thomas J. Hureau   +6 more
wiley   +1 more source

Bradykinin-induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways

, 2013
Bradykinin drives normal lung fibroblasts into myofibroblasts, induces fibroblast proliferation and activates mitogen activated protein kinase pathways (MAPK) but its effects on bronchial fibroblasts from asthmatics (HBAFb) have not been yet studied.
Fabbri, Leonardo M., Antonino Di Stefano, Anna M. Longo, Petecchia, Loredana, Sabatini, Federica, Alessandra Eva, Fabrizio Luppi, Ricciardolo, Fabio L. M., Sterk, Peter J., Vanni, Cristina, Longo, Anna M., Luppi, Fabrizio, Peter J. Sterk, Eva, Alessandra, Rossi, Giovanni A., Cristina Vanni, Federica Sabatini, Pieter S. Hiemstra, Giovanni A. Rossi, FABBRI, Leonardo, Loredana Petecchia, Stefano, Antonino Di, Hiemstra, Pieter S., Sorbello, Valentina, Valentina Sorbello, Fabio L. M. Ricciardolo   +25 more
core   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, Volume 183, Issue 20, Page 5999-6006, October 2026.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Envolvimento dos receptores B1 e B2 para as cininas na hiperatividade da bexiga urinária induzida por lesão medular em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2011O envolvimento dos receptores B1 e B2 para as cininas em processos fisiopatológicos da bexiga ...
Forner, Stefânia
core  

Bradykinin and Neuronal Injury

, 1992
Bradykinin, a nine-amino-acid peptide formed from a large precursor polypeptide (kininogen) by the action of the enzyme kallikrein (kininogenase), is the initial mediator of inflammation, and, in particular, bradykinin induces pain and alters vascular ...
Paul C. Francel
core   +1 more source

Assessing the impact of a rare synonymous variant in the KNG1 gene on the development of hereditary angioedema

Медицинская иммунология
The main cause of edema in hereditary angioedema (HAE) is due to elevated bradykinin levels, caused either by C1-INH deficiency/change in functional activity and caused by mutations in the SERPING1 gene or by mutations in the F12, PLG, ANGPT1, KNG1, MYOF
N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. A. Totolian   +4 more
doaj   +1 more source

Cerebral arterial responses to bradykinin.

, 2015
Cerebral arterial responses to bradykinin in BN, FHH, and FHH.1BN rats. *Indicates significant difference from the same concentration of bradykinin between BN and FHH.
Amit Sharma (46604), Kevin R. Rarick (492874), David R. Harder (431167), Richard J. Roman (493017), John D. Imig (838959), Md Abdul Hye Khan (838958)   +5 more
core   +1 more source

Recent Applications of Propylene Carbonate as a Solvent in Sustainable Organic Synthesis

ChemSusChem, Volume 19, Issue 17, 14 September 2026.
This review evaluates propylene carbonate (PC) as a non‐toxic green solvent in organic synthesis, highlighting its performance in key reactions including cross‐couplings, asymmetric hydrogenations, peptide synthesis and biocatalysis. Across these processes, PC delivers yields comparable to conventional and alternative green solvents.
Laura G. Aguilar‐Sanchez, Christopher R. Jones   +1 more
wiley   +1 more source