Results 91 to 100 of about 50,349 (192)

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Bradykinin driven inflammation [PDF]

, 2020
Bradykinin is an inflammatory peptide that causes a local increase in vascular permeability. We have learned from patients with the disease hereditary angioedema that uncontrolled bradykinin production leads to episodes with swelling of submucosal and ...
Hofman, Zonne Liza Michaëla
core  

[Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin interact with B2-bradykinin receptors and stimulate inositol phosphate production in cultured human fibroblasts [PDF]

, 1990
The recently isolated, naturally occurring peptide hormones [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin were investigated for their agonist activity on solubilized binding sites from human fibroblasts. Both ligands competed with [3H]bradykinin binding in
Alexander Faußner, Robert Dengler, Faußner, Alexander, Dengler, Robert, Müller-Esterl, Werner, Adelbert A. Roscher, Roscher, Adelbert A., Werner Müller-Esterl   +7 more
core   +1 more source

Serping1 associated with α-synuclein increase in colonic smooth muscles of MPTP-induced Parkinson’s disease mice

Scientific Reports
Patients with Parkinson’s disease (PD) have gastrointestinal motility disorders, which are common non-motor symptoms. However, the reasons for these motility disorders remain unclear. Increased alpha-synuclein (α-syn) is considered an important factor in
Min Hyung Seo, Soo-Hwan Kim, Sujung Yeo
doaj   +1 more source

Google searches show persistent use of outdated terminology for angioedema in Germany

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Sophia Neisinger, Thomas Buttgereit, Torsten Zuberbier, Markus Magerl   +3 more
wiley   +1 more source

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source

Recombinant Human Tissue Kallikrein-1 for Treating Acute Ischemic Stroke and Preventing Recurrence [PDF]

Novel strategies are needed for the treatment of acute ischemic stroke when revascularization therapies are not clinically appropriate or are unsuccessful.
Volpi, John J., Wambeke, David, Kasner, Scott E., Giuffre, Michael, Bath, Philip M., Masuoka, Lorianne, Madeddu, Paolo R., Hill, Michael D.   +7 more
core   +1 more source

Bradykinin-bradykinin 2 receptor and oxidative stress

Annals of Medicine
Introduction Bradykinin (BK) and its primary receptor, the bradykinin 2 receptor (B2R), play pivotal roles in regulating oxidative stress. While B2R activation has traditionally been linked to elevated reactive oxygen species (ROS) and pro-apoptotic ...
Jun Zhao, Zhuanping Wang, Xuetao Wang, Fangjun Yang, Huirong Xi, Jiantao Wen, Wenjing Zhang, Xiaoming Qiu   +7 more
doaj   +1 more source

Combination of β Adrenergic Receptor Block and Renin–Angiotensin System Inhibition Diminished the Angiotensin II-Induced Vasoconstriction and Increased Bradykinin-Induced Vasodilation in Hypertension

Dose-Response, 2017
In hypertension, the combination therapy is frequently used to obtain a better therapeutic effect and reduce adverse effects. One effective combination is with inhibitors and β-blockers of renin–angiotensin system.
Diego Lezama-Martínez MD, Ignacio Valencia-Hernández PhD, Jazmin Flores-Monroy PhD, Luisa Martínez-Aguilar PhD   +3 more
doaj   +1 more source