Results 51 to 60 of about 44,634 (185)

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source

Using MALDI‐FTICR Mass Spectrometry to Enhance ZooMS Identifications of Pleistocene Bone Fragments Showing Variable Collagen Preservation

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Recent advances in high‐throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have permitted breakthroughs in the analysis of archaeological material that is highly fragmented, a factor that hinders morphological identification.
Pauline Raymond, Karen Ruebens, Fabrice Bray, Jean‐Christophe Castel, Eugène Morin, Foni Le Brun‐Ricalens, Jean‐Guillaume Bordes, Christian Rolando, Jean‐Jacques Hublin   +8 more
wiley   +1 more source

Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy

Frontiers in Medicine, 2018
Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied.
Carlos C. Barros, Ines Schadock, Ines Schadock, Gabin Sihn, Franziska Rother, Ping Xu, Elena Popova, Irina Lapidus, Ralph Plehm, Arnd Heuser, Mihail Todiras, Sebastian Bachmann, Natalia Alenina, Natalia Alenina, Ronaldo C. Araujo, Joao B. Pesquero, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader   +21 more
doaj   +1 more source

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source

Evaluation of Post‐Endodontic Pain Reduction Using Intracanal Cryotherapy in Symptomatic Apical Periodontitis

Australian Endodontic Journal, EarlyView.
ABSTRACT This prospective experimental study evaluated the efficacy of intracanal cryotherapy in reducing postoperative pain in patients with symptomatic apical periodontitis. Ninety participants with necrotic pulp and preoperative pain (VAS ≥ 7) were randomised into two groups: Group A received room‐temperature saline irrigation, while Group B ...
Anam Fayyaz Bashir, Ussamah Waheed Jatala, Muhammad Amber Fareed, Sheryar Sheryar, Saadia Ahmad Chattha, Saima Razaq Khan, Shahzad Ahmad, Shazia Iqbal, Muhammad Sohail Zafar, Shahzad Ali   +9 more
wiley   +1 more source

PROTECTIVE EFFECT OF LIGNOCAINE AGAINST ACETYLCHOLINE AND BRADYKININ INDUCED TRACHEAL TISSUE CONTRACTION

Pakistan Armed Forces Medical Journal, 2019
Objective: To evaluate the protective effect of lignocaine against acetylcholine and bradykinin induced airway contraction of isolated tracheal tissue of guinea pig in vitro. Study Design: Laboratory based quasi experimental study.
Fatima Qasim Malik, Bushra Tayyaba Khan, Mahjabeen Sharif   +2 more
doaj  

Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

Cell Reports, 2019
Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
ATP has broad functions as an autocrine/paracrine molecule. The mode of ATP release and its intracellular source, however, are little understood. Here we show that bradykinin via B2-receptor stimulation induces the extracellular release of ATP via the ...
Yumei Zhao, Keisuke Migita, Chiemi Sato, Sadaharu Usune, Takahiro Iwamoto, Takeshi Katsuragi   +5 more
doaj   +1 more source

Elucidation of the zinc binding site in KCNQ channels

British Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang, Xinhe Yang, Meng Yang, Yixue Cao, Sai Shi, Nikita Gamper, Haixia Gao   +6 more
wiley   +1 more source