Results 201 to 210 of about 1,270,647 (242)
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Bradykinin receptor ligands: therapeutic perspectives
Nature Reviews Drug Discovery, 2004Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-acting peptides that have broad effects mediated by two related G-protein-coupled receptors termed the bradykinin receptors. The endogenous kallikrein-kinin system controls blood circulation and kidney function, and promotes inflammation and pain in pathological ...
François, Marceau, Domenico, Regoli
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Therapeutic prospects of bradykinin receptor antagonists
General Pharmacology: The Vascular System, 19931. Bradykinin and related kinins may act on four types of receptors designated as B1, B2, B3 and B4. It seems that the B2 receptors are most commonly found in various vascular and non-vascular smooth muscles, whereas B1 receptors are formed in vitro during trauma, and injury, and are found in bone tissues. 2.
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Intracellular and nuclear bradykinin B2 receptors
European Journal of Pharmacology, 2014Bradykinin is a vasoactive peptide that participates in numerous inflammatory processes, vasodilation, and cell growth/survival; it mainly acts through two receptor subtypes, bradykinin B1 and bradykinin B2 receptors, which are G protein-coupled receptor (GPCR) family members.
Masaoki Takano, Shogo Matsuyama
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Journal of Medicinal Chemistry, 2012
The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual B1 and B2 antagonist, novel antagonists were designed that display low-nanomolar affinity for human B1 receptor and selectivity over B2.
Martine, Barth +7 more
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The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual B1 and B2 antagonist, novel antagonists were designed that display low-nanomolar affinity for human B1 receptor and selectivity over B2.
Martine, Barth +7 more
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Bradykinin receptor antagonists.
IDrugs : the investigational drugs journal, 2005A review of the recent patent literature for bradykinin B2 receptor antagonists is presented for the period of 1994 to 1998. Although several very potent and selective peptide antagonists of bradykinin receptors are already known, the increasing number of recently disclosed patent applications claiming non-peptide B2 antagonists represents substantial ...
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Differentiation of Bradykinin Receptors and of Kininases with Conformational Analogues of Bradykinin
Molecular Pharmacology, 1978L E, LeDuc, G R, Marshall, P, Needleman
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