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ACE inhibitor-induced bradykinin-mediated angioedema presenting as small bowel obstruction and life-threatening airway angioedema: a rare dual presentation. [PDF]
BMJ Case RepGhimire P, Sathya DA, Tang A, Yaqoob H.
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Bradykinin receptors and their antagonists
European Journal of Pharmacology, 1998Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on plasma membranes of cells expressing the native or the transfected human kinin B1 or B2 receptor types.
Anna Rizzi +2 more
exaly +3 more sources
Receptors for bradykinin and kallidin
Canadian Journal of Physiology and Pharmacology, 1979In order to establish if bradykinin (BK) and Lys-bradykinin (Lys-BK), alias kallidin, act on the same or on different receptors, experiments were performed on strips of cat terminal ileum and of rabbit aorta. The first preparation contains receptor B2 and the second has the newly identified receptor B1The criterion used for establishing the identity ...
J N, Drouin, S A, St-Pierre, D, Regoli
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Bradykinin receptor antagonists
Medicinal Research Reviews, 1990Bradykinin and its active metabolites are produced at the sites of their actions by kallikreins. They potently elicit a variety of biological effects: hypotension, bronchoconstriction, gut and uterine contraction, epithelial secretion in airway, gut, and exocrine glands, vascular permeability, pain, connective tissue proliferation, and eicosanoid ...
R M, Burch, S G, Farmer, L R, Steranka
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General Pharmacology: The Vascular System, 1997
1. The last decade has witnessed a phenomenal increase in our understanding of the pharmacology of bradykinin receptors, and has led to an appreciation of a key role for the peptide kinins as proinflammatory mediators. This short review summarises the major changes that have taken place in the expanding area of bradykinin receptor pharmacology, and ...
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1. The last decade has witnessed a phenomenal increase in our understanding of the pharmacology of bradykinin receptors, and has led to an appreciation of a key role for the peptide kinins as proinflammatory mediators. This short review summarises the major changes that have taken place in the expanding area of bradykinin receptor pharmacology, and ...
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New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization
Trends in Pharmacological Sciences, 1990Substantial progress has been made recently in the field of kinin pharmacology with the identification of sensitive bioassay organs and the discovery of bradykinin B2 receptor antagonists. Data obtained with such compounds in various laboratories support the hypothesis that kinins act on multiple (at least two) receptor types.
D, Regoli +3 more
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Bradykinin Receptors in Ischemic Injury
Current Neurovascular Research, 2019Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation,
Min, Tang +5 more
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Receptors for bradykinin in rabbit aortae
Canadian Journal of Physiology and Pharmacology, 1977Rabbit aorta strips respond to bradykinin (BK) and to the C-terminal fragment of BK, the octapeptide 1-8 BK (Octa) with sustained contractions which are presumably due to the stimulation of specific receptors, because they remain unchanged in presence of phentolamine, methysergide, mepyramine, 8-Leu-ATII, and indomethacin.
D, Regoli, J, Barabé, W K, Park
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Theoretical Study of the Human Bradykinin–Bradykinin B2 Receptor Complex
ChemBioChem, 2008AbstractThe interaction of bradykinin (BK) with the bradykinin B2 receptor (B2R) was analyzed by using molecular modeling (MM) and molecular dynamics (MD) simulations. A homology model for B2R has been generated and the recently determined receptor‐bound solid‐state NMR spectroscopic structure of BK (Lopez et al., Angew. Chem.
Artur Giełdoń +3 more
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