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The multifaceted anti-cancer effects of BRAF-inhibitors. [PDF]
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Radiosensitization by BRAF inhibitors
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2017BackgroundIncreased skin toxicity during combination therapy with a BRAF inhibitor and radiation therapy has recently been reported.Material and MethodsWe present seven melanoma patients with non‐resectable stage III or IV disease and concomitant treatment with a BRAF inhibitor and radiation therapy.ResultsIn all patients, combination therapy yielded a
Strobel, Sophia Boyoung +5 more
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Overcoming Drug Resistance to BRAF Inhibitor
Bulletin of Mathematical Biology, 2020One of the most frequently found mutations in human melanomas is in the B-raf gene, making its protein BRAF a key target for therapy. However, in patients treated with BRAF inhibitor (BRAFi), although the response is very good at first, relapse occurs within 6 months, on the average.
Friedman, Avner, Siewe, Nourridine
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