Results 171 to 180 of about 103,219 (202)

MEK Inhibition in BRAF-Mutated Melanoma

New England Journal of Medicine, 2012
Korrespondenz zu 10.1056 ...
Flaherty, Keith T., Robert, Caroline, Schadendorf, Dirk   +2 more
openaire   +4 more sources

Melanom mit BRAF-Mutation

Onkologische Welt, 2021
Ob in der Erstlinientherapie des fortgeschrittenen Melanoms – bei Vorliegen einer BRAF-Mutation – lieber eine Immuntherapie oder eine zielgerichtete Therapie eingesetzt werden sollte, wird kontrovers diskutiert. Beim 30. Deutschen Hautkrebskongress wurde Ende 2020 die Datenlage zu diesen Themen aufgegriffen und Argumente für die einzelnen ...
openaire   +1 more source

BRAF mutations in pediatric metanephric tumors

Human Pathology, 2015
Metanephric neoplasms of the kidney are uncommon, and some cases are associated with papillary carcinoma. Most cases of metanephric adenoma occur in adults, with fewer than 25 cases reported in children, and metanephric adenofibroma is even less common.
Rose, Chami, Minzhi, Yin, Paula, Marrano, Chinachote, Teerapakpinyo, Shanop, Shuangshoti, Paul Scott, Thorner   +5 more
openaire   +2 more sources

BRAF Mutations in Lung Cancer.

Acta cytologica, 2019
Dear Editor, With great interest we read the paper by Salimian et al. [1], describing the distribution of different v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations in lung adenocarcinomas (ADCs), which has recently been published in Acta Cytologica.
Pisapia P., Pepe F., Malapelle U., Troncone G.   +3 more
openaire   +2 more sources

BRAF V600E Mutations in Endometrial Adenocarcinoma

Diagnostic Molecular Pathology, 2013
The BRAF V600E somatic mutation is recognized as an oncogenic driver of many human cancers involving the MAPK/ERK pathway. Colorectal and lung cancers associated with the BRAF V600E mutation often demonstrated mucinous morphology. This study hypothesized that the BRAF V600E mutation may be associated with mucinous morphology in endometrial cancer and ...
Mai, He, Virginia, Breese, Steven, Hang, Cunxian, Zhang, Jinjun, Xiong, Cynthia, Jackson   +5 more
openaire   +2 more sources

BRAF Mutation-Positive Folliculotropic Metastatic Melanoma

The American Journal of Dermatopathology, 2013
Primary cutaneous folliculotropic melanoma has been described rarely, and there are even fewer published cases of folliculotropic metastases. We report a 54-year-old man with history of primary cutaneous melanoma of the right posterior shoulder, Breslow depth of 3.4 mm, with one positive sentinel lymph node, negative full axillary dissection, and no ...
Katherine E, Brick, Kevin C, Halling, Yulia K, Khan, Margot S, Peters   +3 more
openaire   +2 more sources

BRAF inhibitors in BRAF-V600 mutated primary neuroepithelial brain tumors

Expert Opinion on Investigational Drugs, 2015
Primary neuroepithelial brain tumors encompass a wide variety of glial and glioneuronal neoplasms. Malignant tumors, tumors located in surgically inaccessible locations (e.g., eloquent brain areas, deep structures, brain stem) and recurrent or progressive tumors pose considerable treatment challenges and are candidates for novel therapeutics based on ...
Matthias, Preusser, Michal, Bienkowski, Peter, Birner   +2 more
openaire   +2 more sources

BRAF/MEK inhibition in melanoma patients with rare BRAF mutations.

Journal of Clinical Oncology, 2018
9542Background: BRAF/MEK inhibition is standard of care in patients (pts) with a BRAF V600E/K mutated melanoma. Efficacy data for pts with less frequent BRAF mutations are limited so far.
Hassel, Jessica Cecile, Menzer, Christian, Menzies, Alexander M., Carlino, Matteo S., Long, Georgina V., Kefford, Richard, Eigentler, Thomas K., Johnson, Douglas Buckner, Schlaak, Max, Meiss, Frank, Schilling, Bastian, Gutzmer, Ralf, Pföhler, Claudia, Meier, Friedegund Elke, Zimmer, Lisa, Haalck, Thomas, Thoms, Kai, Kopp-Schneider, Annette, Enk, Alexander   +18 more
openaire   +1 more source

Impact of BRAF mutation and BRAF inhibition on melanoma brain metastases

Melanoma Research, 2015
The impact of BRAF mutations in metastatic melanoma on the incidence of brain metastases and melanoma prognosis and the effect of BRAF inhibitors on the incidence of brain metastases has not been defined. Therefore, a retrospective analysis of patients with metastatic melanoma treated at three institutions was carried out to examine the impact of BRAF ...
Gummadi T, Zhang BY, VALPIONE, SARA, Kim C, Kottschade LA, Mittapalli RK, Chiarion Sileni V, Pigozzo J, Elmquist WF, Dudek AZ   +9 more
openaire   +3 more sources

BRAF-Mutated Glioma

2023
Karisa C. Schreck, Jean M. Mulcahy Levy
openaire   +1 more source