Results 101 to 110 of about 187,908 (321)

The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents: a meta-analysis

Neural Regeneration Research
Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels
Xueyun Shao, Longfei He, Yangyang Liu
doaj   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor (BDNF)

Nauchno-prakticheskii zhurnal «Patogenez», 2019
Сегодня нейротрофический фактор мозга (BDNF) - вещество очень популярное. Большой интерес к белку объясняется его участием в важнейших для жизни и здоровья процессах: нервной регуляции, углеводном и липидном обмене, адаптации к физическим нагрузкам.
openaire   +3 more sources

Psychiatric disorders and brain-derived neurotrophic factor test: A summary on clinical reports

Journal of the Scientific Society
Brain-derived neurotrophic factor is a neurotrophin that is related to canonical nerve growth factor (BDNF). The protein BDNF is produced by the human nervous system.
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit   +1 more
doaj   +1 more source

Neurotrophic Factors in Multiple Sclerosis: a Review of the Mechanism [PDF]

Neurology Letters
The objective of this review is to examine the mechanistic roles of neurotrophic factors (NTFs) in the pathology of multiple sclerosis (MS) and their potential as therapeutic agents. MS is a chronic autoimmune disease of the central nervous system (CNS),
Samaneh Azizpour, Vahid Moghadasi
doaj   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Clinical Importance of Serum BDNF (Brain Derived Neurotrophic Factor) Level for the Management of Pregnancies Complicated with Meconium-Stained Amniotic Fluid

Diyala Journal of Medicine
Background: Meconium-stained amniotic fluid complicates pregnancies and is associated with high risk of neonatal meconium aspiration syndrome. Early detection of meconium-stained amniotic fluid is essential to prevent adverse neonatal outcomes ...
Firdaws Midhat Jihad, Esraa Abdulkareem Mohammed   +1 more
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents

Environmental Health and Preventive Medicine, 2017
Background Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of ...
Yong Kyun Jeon, Chang Ho Ha
doaj   +1 more source