Results 141 to 150 of about 236,444 (370)

Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF

Journal of Neuroinflammation, 2018
Background The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of caloric intake and energy expenditure.
Albina F. Ramalho, Bruna Bombassaro, Nathalia R. Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A. Velloso, Eliana P. Araujo   +8 more
doaj   +1 more source

Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications

Journal of Ophthalmology, 2020
Impairment of neuroprotection and vasculopathy are the main reasons for the progression of diabetic retinopathy. In this review, we decided to illustrate the molecular and clinical aspects of diabetic retinal neuro-vasculopathy.
Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi   +2 more
doaj   +1 more source

Impact of brain‐derived neurotrophic factor genetic polymorphism on cognition: A systematic review

Brain and Behavior, 2018
Brain‐derived neurotrophic factor (BDNF) has an important role in the neurogenesis and neuroplasticity of the brain. This systematic review was designed to examine the association between BDNF Val66Met (rs6265) polymorphism and four cognitive domains ...
Y. L. Toh, Terence Ng, M. Tan, A. Tan, A. Chan   +4 more
semanticscholar   +1 more source

Brain-derived neurotrophic factor, stress and depression: A minireview

Brain Research Bulletin, 2009
Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression are rapidly replicating.
Kilic, Ertugrul, Ozan, Erol, GÖNÜL, ALİ SAFFET, Yulug, Burak   +3 more
openaire   +4 more sources

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury

Neural Regeneration Research
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited. Microglia is the resident immune cells of the central nervous system, play a critical role in spinal cord injury. Previous studies
Fanzhuo Zeng, Yuxin Li, Xiaoyu Li, Xinyang Gu, Yue Cao, Shuai Cheng, He Tian, Rongcheng Mei, Xifan Mei   +8 more
doaj   +1 more source

Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction

Advanced Science, EarlyView.
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu, Huitong Ruan, Xiaolin Zhang, Weihan Zheng, Muhetaierjiang Mutailifu, Ling Wang, Liu Yu, Ruijun Peng, Rui Zhao, Zihan Wang, Jie Xu, Shaochuan Li, Yaobin Wu, Wenguo Cui, Mujun Lu   +14 more
wiley   +1 more source

Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Neural Regeneration Research
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor.
Yiyang Qin, Wenzhen Zhu, Tingting Guo, Yiran Zhang, Tingting Xing, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang   +8 more
doaj   +1 more source

CLINICAL AND DIAGNOSTIC VALUE OF PEROXYNITRITE AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN INFANTS WITH PERINATAL HYPOXIC LESIONS OF THE CNS

Медицинский вестник Юга России, 2013
Purpose: To determine the diagnostic value of peroxynitrite and brain-derived neurotrophic factor in the genesis of perinatal lesions of the central nervous system.Materials and methods: 67 children were comprehensive survey during the first three months
A. A. Afonin, I. G. Loginova, E. A. Papsheva, S. G. Bobrova, N. A. Drukker   +4 more
doaj   +1 more source

Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine [PDF]

, 1994
Mathew T. Martin‐Iverson, KG Todd, C. Anthony Altar   +2 more
openalex   +1 more source