Results 141 to 150 of about 244,575 (365)

The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis

PLoS ONE, 2016
Background The mechanisms through which physical activity supports healthy brain function remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic factor (BDNF) mediates some cognitive and mood benefits.
Adam Dinoff, N. Herrmann, W. Swardfager, Celina S. Liu, Chelsea Sherman, Sarah Chan, K. Lanctôt   +6 more
semanticscholar   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease

Revista Habanera de Ciencias Médicas
Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying levels.
Naybí Prendes Rivero, Levis Verde Corvo, Belkis López González, Iris Dany Carmenate Rodríguez, Nibaldo B Mesa Hernández, María A Robinson Agramonte   +5 more
doaj  

Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Neural Regeneration Research
Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor.
Yiyang Qin, Wenzhen Zhu, Tingting Guo, Yiran Zhang, Tingting Xing, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang   +8 more
doaj   +1 more source

CLINICAL AND DIAGNOSTIC VALUE OF PEROXYNITRITE AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN INFANTS WITH PERINATAL HYPOXIC LESIONS OF THE CNS

Медицинский вестник Юга России, 2013
Purpose: To determine the diagnostic value of peroxynitrite and brain-derived neurotrophic factor in the genesis of perinatal lesions of the central nervous system.Materials and methods: 67 children were comprehensive survey during the first three months
A. A. Afonin, I. G. Loginova, E. A. Papsheva, S. G. Bobrova, N. A. Drukker   +4 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells [PDF]

, 2017
Xinxin Guo, Qing‐zhi He, Wu Li, Dingxin Long, Xiaoyuan Pan, Cong Chen, Huaicai Zeng   +6 more
openalex   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

Molecules
Microglia, the brain immune cells, support neurons by producing several established neurotrophic molecules including glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF).
Kennedy R. Wiens, Naved Wasti, Omar Orlando Ulloa, Andis Klegeris   +3 more
doaj   +1 more source

RELATIONSHIPS BETWEEN PARKINSON S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS

, 2021
Tuba Ekmekyapar
openalex   +1 more source

Expression of Growth Associated Protein-43 (GAP-43) and Brain-derived Neurotrophic Factor (BDNF) from Adipose Mesenchymal Stem Cells (ASC) with fresh frozen nerve scaffold in 5% hypoxic condition [PDF]

, 2021
I Putu Gede Pradnyadewa Pradana, Asra Al Fauzi, Heri Suroto   +2 more
openalex   +1 more source