Results 21 to 30 of about 249,425 (238)

The role of brain derived neurotrophic factor in central nervous system

Frontiers in Aging Neuroscience, 2022
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological
Yiyi Li, Fang Li, Dongdong Qin, Hongyu Chen, Jianhao Wang, Jiabei Wang, Shafei Song, Chao Wang, Yamei Wang, Songyan Liu, Dandan Gao, Zhi-Hao Wang   +11 more
semanticscholar   +1 more source

Assessment of attention, memory, and salivary brain-derived neurotrophic factor in chronic smokers: A cross-sectional observational study

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Objective: Chronic smoking leads to cognitive impairments and affects the peripheral brain-derived neurotrophic factor (BDNF) levels. BDNF is responsible for synaptic plasticity and memory.
A Srividya, A Kannan, C L Krithika, K Yesoda Aniyan   +3 more
doaj   +1 more source

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., John, J., Sendtner, M., Wittinghofer, A.   +5 more
core   +2 more sources

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

Journal of Neural Transplantation and Plasticity, 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson   +5 more
semanticscholar   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

Frontiers in Cellular Neuroscience, 2019
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes related to learning and memory. The expression of BDNF is highly regulated, and can lead to great variability in BDNF levels in healthy subjects.
M. Miranda, J. F. Morici, M. B. Zanoni, P. Bekinschtein   +3 more
semanticscholar   +1 more source

Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels

Clinics, 2010
OBJECTIVE: Blood neurotrophins, such as the brain-derived neurotrophic factor, are considered to be of great importance in mediating the benefits of physical exercise.
Paulo Roberto Correia, Aline Pansani, Felipe Machado, Marilia Andrade, Antonio Carlos da Silva, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Ricardo Mario Arida   +7 more
doaj   +1 more source

Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of parkinson's disease [PDF]

, 2011
BACKGROUND: Glial cell-derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved.
Ansorena-Artieda, E. (Eduardo), Aymerich-Soler, M. S. (María S.), Blanco-Prieto, M.J. (María José), Garbayo, E, Lanciego, J.L. (José Luis)   +4 more
core   +1 more source

Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non–small cell lung caner

Tumor Biology, 2017
In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non–small cell lung cancer.
MingJing Shen, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, ZhongHeng Xu   +5 more
doaj   +1 more source