Results 21 to 30 of about 236,444 (370)
International Journal of Molecular Sciences, 2022 Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar +1 more source
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
Translational Neurodegeneration, 2022 Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic ...
Li Gao +3 more
semanticscholar +1 more source
Frontiers in Physiology, 2022 Background: Aerobic exercise could produce a positive effect on the brain by releasing brain-derived neurotrophic factor (BDNF). In untrained healthy humans there seems to be a linear correlation between exercise duration and the positive effect of acute
Kegang Zhao +7 more
doaj +1 more source
The role of brain derived neurotrophic factor in central nervous system
Frontiers in Aging Neuroscience, 2022 Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological
Yiyi Li +11 more
semanticscholar +1 more source
Brain-derived neurotrophic factor in the airways [PDF]
Pharmacology & Therapeutics, 2014 In addition to their well-known roles in the nervous system, there is increasing recognition that neurotrophins such as brain derived neurotrophic factor (BDNF) as well as their receptors are expressed in peripheral tissues including the lung, and can thus potentially contribute to both normal physiology and pathophysiology of several diseases.
Richard J. Martin, Y. S. Prakash
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Journal of Neural Transplantation and Plasticity, 2022 Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims +5 more
semanticscholar +1 more source
Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023 Objective: Chronic smoking leads to cognitive impairments and affects the peripheral brain-derived neurotrophic factor (BDNF) levels. BDNF is responsible for synaptic plasticity and memory.
A Srividya +3 more
doaj +1 more source
Brain-derived neurotrophic factor in primary headaches [PDF]
The Journal of Headache and Pain, 2012 Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide.
Fischer, Marlene +6 more
openaire +4 more sources
Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]
, 1989 Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A. +5 more
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Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young adults study. [PDF]
, 2023 BACKGROUND: Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of ...
Bryan, R +6 more
core +1 more source