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Brain-derived neurotrophic factor in neurodegenerative diseases
Nature Reviews Neurology, 2009Changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders, including Huntington disease, Alzheimer disease and Parkinson disease. It is only in Huntington disease, however, that gain-of-function and loss-of-function experiments have ...
C. Zuccato, E. Cattaneo
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Brain-Derived Neurotrophic Factor in Neonatal Seizures
Pediatric Neurology, 2021Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has an extensively studied classical role in neuronal growth, differentiation, survival, and plasticity. Neurotrophic, from the Greek neuro and trophos, roughly translates as "vital nutrition for the brain." During development, BDNF and its associated receptor tyrosine ...
Brennan J. Sullivan +2 more
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Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor in Patients with Depression [PDF]
Neurochemical Journal, 2020 Abstract—We studied the content of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) in serum and lacrimal fluid in 105 patients with depression (unipolar depression, 37 and bipolar depression, 68). The stimulated lacrimal fluid was taken from one randomly selected eye with a pipette dispenser.
Natalia V. Gulyaeva +4 more
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Brain-derived neurotrophic factor in multiple sclerosis
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019The review presents data on brain-derived neurotrophic factor (BDNF), its structure and functions, the effect on the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis (MS). The correlation of BDNF level with clinical manifestations of MS and the changes of its level during disease-modifying therapy is considered.
M. Titova +4 more
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Brain‐derived neurotrophic factor and post‐stroke depression
Journal of Neuroscience Research, 2019Brain‐derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level
Eric T. Zhang, Ping Liao
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The effect of brain-derived neurotrophic factor on angiogenesis
Journal of Huazhong University of Science and Technology [Medical Sciences], 2009To investigate the in vitro and in vivo proangiogenic effects of brain-derived neurotrophic factor (BDNF), human umbilical vein endothelial cells (HUVECs) were isolated and cultured in primary culture. The effect of BDNF on the proliferation of HUVECs was examined by MTT assay.
Zhang-Bo Chu +4 more
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Brain-derived neurotrophic factor in human platelets
Biochemical Pharmacology, 1997A sensitive, capture enzyme-linked immunosorbent assay (CELISA) has been applied to the accurate and reproducible measurement of brain-derived neurotrophic factor (BDNF) protein in normal human blood platelets, a mean concentration of 1.03 +/- 0.04 ng (SEM)/mg of platelet protein being observed.
F.Bernardo Pliego-Rivero +6 more
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Brain-Derived Neurotrophic Factor and Antidepressant Activity
Current Pharmaceutical Design, 2005Brain-derived neurotrophic factor (BDNF) is a member of the structurally and functionally homologous neurotrophin family. It is the most widely distributed trophic factor in the brain, and participates in neuronal growth, maintenance, and use-dependent plasticity mechanisms such as long-term potentiation and learning.
A A Russo-Neustadt, M J Chen
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Brain-derived neurotrophic factor in Huntington disease
Brain Research, 2000Trophic factors, administered systemically or delivered via genetically-modified cells grafted into target regions, have been proposed as putative therapeutic agents in human neurodegenerative disorders. In parallel to the study of the beneficial effects in experimental models of particular diseases, a crucial aspect of the study of trophic factors is ...
E Goutan +4 more
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Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation
The Neuroscientist, 2018Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that now spans 35 years of research. While all neurotrophins share considerable overlap in sequence homology and their processing, BDNF has become the most widely ...
M. Notaras, M. van den Buuse
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