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Brain-derived neurotrophic factor in Huntington disease
Brain Research, 2000Trophic factors, administered systemically or delivered via genetically-modified cells grafted into target regions, have been proposed as putative therapeutic agents in human neurodegenerative disorders. In parallel to the study of the beneficial effects in experimental models of particular diseases, a crucial aspect of the study of trophic factors is ...
E Goutan +4 more
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Brain derived neurotrophic factor and neurodegeneration
Expert Opinion on Therapeutic Patents, 1999Brain derived neurotrophic factor (BDNF) was the subject of over one hundred patents in the past three years. The majority of these patents propose new methods to increase its bioavailability and clinical benefit (that is yet to be defined in the adult human nervous system).
Cristian L. Achim, Michael G. White
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Brain-derived neurotrophic factor: findings in schizophrenia
Current Opinion in Psychiatry, 2011To review the role of brain-derived neurotrophic factor (BDNF) in neuroplasticity related to schizophrenia and the recent findings that have been reported on the status of BDNF in patients with schizophrenia and its association with the clinical measures.Peripheral BDNF levels have been found altered in first-episode patients with psychosis and also in
Peter F. Buckley +2 more
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Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into Regulation and Genetic Variation
The Neuroscientist, 2018Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that now spans 35 years of research. While all neurotrophins share considerable overlap in sequence homology and their processing, BDNF has become the most widely ...
M. Notaras, M. van den Buuse
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Phylogenesis of brain-derived neurotrophic factor (BDNF) in vertebrates
Gene, 2010Brain-derived neurotrophic factor (BDNF) belongs to neurotrophin family, a class of molecules playing key roles in neuronal development, survival and regeneration, neurite growth and plasticity: memory processes are mainly affected, and mutations of the human BDNF gene are associated to cognitive and behavioural disturbances.
TETTAMANTI, GIANLUCA +5 more
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Brain-derived neurotrophic factor as a suicide factor in mental disorders
Acta Neuropsychiatrica, 2013ObjectiveBrain-derived neurotrophic factor (BDNF) plays a critical role in brain plasticity processes and serum levels have been demonstrated to be altered in patients with different mental disorder including suicidal behaviour. The objective of this study was to examine the association between serum BDNF levels as a possible peripheral indicator of ...
Sven Molnar +5 more
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Brain-Derived Neurotrophic Factor and Rett Syndrome
2014Rett syndrome (RTT) is a devastating neurodevelopmental disorder with autistic features caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2), a transcriptional regulatory protein. RTT has attracted widespread attention not only because of the urgent need for treatments, but also because it has become a window ...
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Brain-Derived Neurotrophic Factor
Drugs of the Future, 1997Bertold Schrank, Michael Sendtner
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Molecular cloning and expression of brain-derived neurotrophic factor
Nature, 1989J. Leibrock +7 more
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