Results 201 to 210 of about 2,520,525 (306)

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Transcriptomic Evidence of Mitochondrial Double-Stranded RNA Accumulation in Brain Aging and Alzheimer's Disease. [PDF]

Aging Cell
Doser RL, LaRocca TJ.
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

The exposome of brain aging across 34 countries. [PDF]

Nat Med
Legaz A, Moguilner S, Barttfeld P, Cuadros Castro J, Galván Rial DS, Migeot J, Farina FR, Gonzalez-Gomez R, Salazar-Londoño S, de Souza Azzi T, Alcauter S, Amoruso L, Anghinah R, Bakr M, Behrens MI, Bruno MA, Cardona JF, Chen C, Colliot O, Custodio N, d'Acremont Q, Debette S, Dzianok P, Güntekin B, Huguet J, Jarne C, Joliot M, Karageorgiou E, Khedr EM, Koopowitz SM, Kublik E, Lee J, Aksman L, Lopez S, Margaretic P, Matallana D, Matis S, Miltiadous A, Novotni G, Orio P, Parra MA, Reppermund S, de Paula França Resende E, Salum GA, Slachevsky A, Ortiz ALS, Takada LT, Toh AQ, Tzallas A, Wen W, Whelan R, Yener G, Zegarra Valdivia JA, Alexoudi A, Arshad F, Atta H, Avila-Funes JA, Santos JB, Bruña R, Castelblanco-Toro SM, Chino Vilca BN, Coronel-Oliveros C, Crivello F, Cruzat J, Dellavale D, Dhooge C, Di Caterina G, Escudero J, Esquivias Farias JM, Eze LU, Evans TE, Farombi T, Fernández A, Fittipaldi S, Portillo F, Martinic GF, García AM, Garcia-Cordero I, Gaurav R, Godoy ME, Gonzalez Campo C, González Hernández A, Hanoğlu L, Hazelton JL, Herzog R, Ikiz B, Njamnshi AK, Landin-Romero R, López ME, Maito MA, Medel V, Sepúlveda JPM, Ochoa Gómez JF, Ogbuagu C, de Oliveira MO, Ozansoy M, Palma-Espinosa J, Hilal S, Zhou JH, Escudero SDP, Pitman JK, Prado P, Ramírez González D, Reyes P, Santamaría García H, Schröder J, Sitt JD, Soliman RK, Soto-Añari M, Thanissery N, Ito LT, Tsuchida A, Tzourio C, Yırıkoğulları H, Yokoyama JS, Aguillon D, Miller B, Alladi S, Jiang Y, Navarro A, Babiloni C, Huepe Artigas D, Piguet O, Sosa PAV, Mostert CM, Tahmasian M, Li P, Hu K, Genon S, Stein DJ, Maestú F, Pievani M, Salama M, Brodaty H, Sachdev PS, Lawlor B, Eyre HA, Miranda JJ, Baez S, Tagliazucchi E, Duran-Aniotz C, Hernandez H, Ibanez A.   +142 more
europepmc   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

Histone modification dynamics in brain aging: unlocking therapeutic potential. [PDF]

Cell Death Dis
Chang B, Yang S, Yilixiati A, Zhang F, Sun X, Wang L, Hu B, Zhou Y.   +7 more
europepmc   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

Brain aging patterns among nine neurological disorders: A case-control study. [PDF]

PLoS Med
Liang C, Pearlson G, Bustillo J, Kochunov P, Chen J, Zhang X, Jiang R, Hutchison KE, Sui J, Fu Z, Yang X, Du Y, Zhang D, Qi S, Calhoun VD.   +14 more
europepmc   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source