Results 81 to 90 of about 2,520,525 (306)

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging [PDF]

, 2007
Brummelte S, Teuchert-Noodt G. Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions.
Teuchert-Noodt, Gertraud, Susanne Brummelte, Gertraud Teuchert-Noodt, Brummelte, Susanne   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Extracellular vesicle therapy in neurological disorders

Journal of Biomedical Science
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in various physiological and pathological processes. They play crucial roles in immune modulation and tissue regeneration but are also
Napasiri Putthanbut, Jea Young Lee, Cesario V. Borlongan   +2 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Associations Between Cardiovascular Risk Factors and Neurofilament Light Levels Among US Mexican American Adults

Brain and Behavior
Background This study explores the relationship between neurofilament light (NfL) levels, a biomarker of neuronal injury, and cardiovascular health and vascular injury among US Mexican American (MA) and non‐Latino White (NLW) adults.
Monica M. Diaz, Eran Dayan, Health and Aging Brain Study – Health Disparities (HABS‐HD) Study   +2 more
doaj   +1 more source

[Coalition for Aging LGBT Initial Board Exploratory Meeting Document]

, 2015
Initial Board Exploratory Meeting documents from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction An Alzheimer's disease (AD) biomarker adjusted for age‐related brain changes should improve specificity for AD‐related pathological burden. Methods We calculated a brain‐age‐adjusted “personalized AD cortical thickness index” (pADi) in mild ...
Annie M. Racine, Michael Brickhouse, David A. Wolk, Bradford C. Dickerson, Alzheimer's Disease Neuroimaging Initiative   +4 more
doaj   +1 more source

The 'middle-aging' brain

Trends in Neurosciences
Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle age could mark a shift in brain aging. We review emerging evidence on multiple levels of analysis indicating that
Sebastian Dohm-Hansen, Jane A. English, Aonghus Lavelle, Carlos P. Fitzsimons, Paul J. Lucassen, Yvonne M. Nolan   +5 more
openaire   +2 more sources