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Cholesterol and Hydroxycholesterol in the Brain
2011The brain has higher concentration of cholesterol compared to other body parts (25% of the body’s free cholesterol) (Dietschy and Turley, 2004). In brain, cholesterol resides in two pools: one major pool associated with the myelin sheaths playing an important role in propagation of the electrical signals along the axons and the other minor pool ...
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Changes in Brain Cholesterol Metabolome After Excitotoxicity
Molecular Neurobiology, 2010Excitotoxicity due to excess stimulation of glutamate receptors in neurons is accompanied by increased Ca(2+) influx, stimulation of Ca(2+)-dependent enzymes, ATP depletion, increase in lipid peroxidation products, and loss of glutathione. These changes resemble neurochemical alterations in acute neuronal injury (stroke, spinal cord injury, and ...
Ong, Wei-Yi +5 more
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A critical review of brain cholesterol metabolism
1973Publisher Summary This chapter presents a critical review of brain cholesterol metabolism. Modern aspects of brain sterol metabolism are reviewed by Davison and Kabara. Consequently, for this review, the chapter emphasizes only the more recent concepts of brain cholesterol metabolism.
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Cholesterol in cerebrospinal fluid of brain tumor patients
Life Sciences, 1973Abstract A sensitive method for assay of total cholesterol (free plus esterified) in one ml of CSF is presented. Patients with brain tumors showed much higher levels of this sterol in CSF than those with neoplasia external to the central nervous system.
J H, Fleisher +3 more
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Sterol Precursors of Cholesterol in Adult Human Brain
Science, 1968Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites ...
G, Galli, E G, Paoletti, J F, Weiss
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Quantifying brain cholesterol homeostasis
Nature Reviews Drug Discovery, 2022openaire +2 more sources
Cholesterol metabolism in the brain: importance of 24S-hydroxylation
Acta Neurologica Scandinavica, 2006During the last three to four decades there has been an increasing interest in the interaction of circulating and brain cholesterol. Recent in vivo and in vitro studies have furthered our knowledge of cholesterol metabolism in the central nervous system (CNS).
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The influence of testosterone on brain cholesterol.
Endokrinologie, 1976Male sex hormone testosterone propionate induces esterification of brain cholesterol. Esterified cholesterol is absent in the brain of female rats, treatment with male hormone induces esterification. In castrated male rats the esterified cholesterol from brain disappears, whereas supplementation to those animals with testosterone helps in the re ...
S, Chakraborty, A K, Mukherjee
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Brain Cholesterol: The Effect of Chemical and Physical Agents
1967Publisher Summary This chapter discusses the effect of chemical and physical agents on brain cholesterol. The brain represents the largest repository of body cholesterol however relatively little is known about its metabolism and even less about its function and role within the central nervous system.
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