Results 241 to 250 of about 194,987 (288)

Mechanistic role of APOE lipidation in Alzheimer's disease pathogenesis. [PDF]

Theranostics
Zhang DY, Wang J, Dokholyan NV.
europepmc   +1 more source

Lipidomic signatures of CNS ischemic injury and their modulation by immunomodulatory hydrogels.

Analyst
Wang MF, Ouyang Y, Segura T, Muddiman DC.   +3 more
europepmc   +1 more source

Assessment of cholesterol homeostasis in the living human brain [PDF]

Science Translational Medicine, 2022
Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via cytochrome P450 46A1 (CYP46A1).
Ahmed Haider, Chunyu Zhao, Lu Wang, Zhiwei Xiao, Jian Rong, Xiaotian Xia, Zhen Chen, Stefanie K. Pfister, Natalia Mast, Eylan Yutuc, Jiahui Chen, Yinlong Li, Tuo Shao, Geoffrey I. Warnock, Alyaa Dawoud, Theresa R. Connors, Derek H. Oakley, Huiyi Wei, Jinghao Wang, Zhihua Zheng, Hao Xu, April T. Davenport, James B. Daunais, Richard S. Van, Yihan Shao, Yuqin Wang, Ming-Rong Zhang, Catherine Gebhard, Irina Pikuleva, Allan I. Levey, William J. Griffiths, Steven H. Liang   +31 more
core   +6 more sources

Some of the next articles are maybe not open access.

Related searches:

Dietary Cholesterol and the Origin of Cholesterol in the Brain of Developing Rats

Journal of Nutrition, 1991
Milk substitutes containing cholesterol at concentrations lower, equal to or greater than the concentrations found in natural rat milk were fed to artificially reared rat pups from 5 d until 15 or 16 d after birth. Pups reared by their mother served as controls. In one experiment, D7-cholesterol was fed in the milk at four different concentrations. The
John Edmond, Don H Catlin, D H Catlin
exaly   +3 more sources

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2016
Dysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The major elimination pathway of brain cholesterol is its hydroxylation into 24 (S)-hydroxycholesterol by the cholesterol 24-hydroxylase (CYP46A1). Interestingly, there seems to be an association between CYP46A1 and high-order brain functions, in a sense ...
MIGUEL Moutinho, Maria João Nunes, Elsa Rodrigues   +2 more
exaly   +3 more sources

Brain cholesterol in normal and pathological aging

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010
Correct lipid homeostasis at the plasma membrane is essential for cell survival and performance. These are critically challenged in the aging brain. Changes in the levels of cholesterol, a major membrane component especially enriched in neurons, accompany the brain aging process. They also occur in neurodegenerative diseases.
Mauricio G Martin, CARLOS G Dotti, Maria Dolores Ledesma   +2 more
exaly   +3 more sources

Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block [PDF]

Current Neuropharmacology, 2022
The central nervous system (CNS) is enriched with important classes of lipids, in which cholesterol is known to make up a major portion of myelin sheaths, besides being a structural and functional unit of CNS cell membranes.
Xiangning Jiang
exaly   +2 more sources

Cholesterol metabolism in the brain

Current Opinion in Lipidology, 2001
The central nervous system accounts for only 2% of the whole body mass but contains almost a quarter of the unesterified cholesterol present in the whole individual. This sterol is largely present in two pools comprised of the cholesterol in the plasma membranes of glial cells and neurons and the cholesterol present in the specialized membranes of ...
J M, Dietschy, S D, Turley
openaire   +2 more sources

Lack of catabolism of brain cholesterol

Lipids, 1981
AbstractSince direct intracranial injections of precursors indicate that cholesterol is synthesized in the brain at all ages, there must be a mode of disposal also. The sterol nucleus itself is not degraded by mammalian systems but the side chain can be metabolized. [26‐14C] Cholesterol was therefore injected directly into the brain of 80 to 19‐day‐old
G A, Dhopeshwarkar, C, Subramanian
openaire   +2 more sources

Cholesterol in brain disease: sometimes determinant and frequently implicated [PDF]

EMBO Reports, 2014
Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell ...
Mauricio G Martin, Frank W Pfrieger, CARLOS G Dotti   +2 more
exaly   +2 more sources