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Brain Cholesterol Metabolism, Oxysterols, and Dementia [PDF]
Journal of Alzheimer’s Disease, 2013 Cholesterol metabolism is implicated in the etiology of Alzheimer's disease (AD) and amyloid production in the brain. While brain cholesterol cannot be measured directly in vivo, the oxysterol, 24S-hydroxycholesterol (24-OHC), is the predominant metabolite of brain cholesterol and can be measured in the blood.
Timothy M, Hughes +3 more
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Statins and their influence on brain cholesterol
Journal of Clinical Lipidology, 2011Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is not clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones. SOURCES OF MATERIAL: The MEDLINE database.According to the data reported thus far, statins may influence brain cholesterol metabolism directly (
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Brain Cholesterol, Statins and Alzheimer’s Disease
Pharmacopsychiatry, 2003Growing evidence suggests that cellular cholesterol homeostasis is causally involved in different steps leading to pathological events in the brain of Alzheimer's Disease (AD) patients. It was previously demonstrated that the processing of the amyloid beta-peptide precursor protein (APP) is modulated by pronounced alterations in cellular cholesterol ...
C, Kirsch +3 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1971
Abstract 1. 1. The properties and subcellular distribution of the enzymes directly related to the formation and degradation of cholesterol esters were investigated in the young adult rat brain. They were a cholesterol-esterifying enzyme, lecithin-cholesterol acyltransferase, and two distinct cholesterol ester hydrolases. 2. 2. The cholesterol-
Y, Eto, K, Suzuki
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Abstract 1. 1. The properties and subcellular distribution of the enzymes directly related to the formation and degradation of cholesterol esters were investigated in the young adult rat brain. They were a cholesterol-esterifying enzyme, lecithin-cholesterol acyltransferase, and two distinct cholesterol ester hydrolases. 2. 2. The cholesterol-
Y, Eto, K, Suzuki
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Brain cholesterol homeostasis in Wilson disease
Medical Hypotheses, 2013Wilson disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism, resulting in pathological accumulation of Cu in many organs and tissues, predominantly in the liver and brain. There clearly is a close and complex relationship between Cu and the cholesterol's metabolic pathway; therefore any theory about the cholesterol ...
CACCIATORE, STEFANO, TENORI, LEONARDO
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Cholesterol Trafficking in the Brain
2009After it became clear that aberrations in cerebral cholesterol metabolism could lead to severe neurological diseases the interest in the regulation of brain cholesterol homeostasis increased. In particular when evidence was obtained for an important role of cholesterol in the still largely unknown molecular mechanisms underlying Alzheimer’s Disease ...
Dieter Lütjohann +2 more
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Cholesterol metabolism in the myelin of rat brain
Experientia, 1968La persistance de la radioactivite incorporee dans le cholesterol et les lipides totaux de la myeline cerebrale a ete mesuree pendant 200 jours apres un injection i.p. de glucose U-14C chez des rats de 6 semaines ayant donc precisement depasse la periode de myelinisation active et egalement chez des animaux de 6 mois.
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Brain cholesterol metabolism and neurologic disease
Neurology, 2008ABC= : ATP binding cassette; ABCA1= : ABC transporter protein family member A1; AD= : Alzheimer disease; apoE= : apolipoprotein E; APP= : amyloid precursor protein; ATP= : adenosine triphosphate; CoA= : coenzyme A; CYP= : cytochrome P; 7-DHC= : 7-dehydrocholesterol; ER= : endoplasmic reticulum; HD= : Huntington disease;
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Cholesterol: A Two-Edged Sword in Brain Aging
Free Radical Biology and Medicine, 1997Previous research from several laboratories has indicated that cholesterol (CHO) accumulates in neuronal membranes and alters their structural and signal transduction (ST) properties during aging. The possible reasons for these increases in membrane CHO have not been specified. However, present findings suggest that such accumulation may actually serve
J A, Joseph +4 more
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Studies on the synthesis of cholesterol in the brain of the human fetus
American Journal of Obstetrics and Gynecology, 1968Abstract Following the intravenous injection of a single dose of acetate-C 14 to women during early pregnancy, only negligible amounts of isotope could be detected in fetal brain cholesterol, but a significant incorporation of C 14 occurred in cholesterol isolated from the corpus luteum of pregnancy, fetal liver, and fetal adrenals.
E J, Plotz +4 more
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