Results 111 to 120 of about 105,966 (270)

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Malformation syndromes caused by disorders of cholesterol synthesis

Journal of Lipid Research, 2011
Cholesterol homeostasis is critical for normal growth and development. In addition to being a major membrane lipid, cholesterol has multiple biological functions.
Forbes D. Porter, Gail E. Herman
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs

, 2004
Recent epidemiological studies suggest that inhibitors of 3-hydroxy-3-methyl-glutaryl CoA reductase, so-called statins, are effective in lowering the prevalence of Alzheimer's disease.
Thelen, K, Lindenthal, B., Lütjohann, D, Bertsch, T, Kühl, S, Bjorkhem, I., Fassbender, K, von Bergmann, K., Fassbender, Klaus, Andersson, U, Bertsch, Thomas, Kuhl, S., Andersson, U., Stroick, M., Stroick, M, von, Bergmann K, Lutjohann, D., Thelen, Karin M., Björkhem, I,, Lindenthal, B   +19 more
core   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

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Masticatory dysfunction induces astrocyte hyperplasia and disrupts brain cholesterol homeostasis, but the specific mechanism by which unilateral mastication drives cognitive decline remains unclear. A rat model of experimental unilateral mastication (EUM)
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
doaj   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Alteration of cholesterol homeostasis in the Huntington's disease brain

, 2016
Huntington’s disease is a progressive neurodegenerative disease caused by a mutation in the huntingtin protein. Although the mutation has been identified, the molecular mechanisms underlying Huntington’s disease pathology are not fully understood ...
Fabian Kreilaus (9732290)
core  

A hipercolesterolemia como um fator de risco para o desenvolvimento de comprometimento cognitivo leve: evidências obtidas em modelos experimentais [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2013.Evidências acumuladas ao longo das duas últimas décadas sugerem umaassociação positiva entre a ...
Moreira, Eduardo Luiz Gasnhar
core  

Bi-Lateral Changes to Hippocampal Cholesterol Levels During Epileptogenesis and in Chronic Epilepsy Following Focal-Onset Status Epilepticus in Mice

, 2012
Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer\u27s and Huntington\u27s diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are ...
Henshall, David, Meaney, S, Jimenez-Mateos, EM, Engel, Tobias, Al-Aaudia, Reza, Heverin, M, Jimenez-Mateosa, Eva, Engel, T, Henshall, DC, Meaney, Steve, Heverin, Maura, Al-Saudi, R   +11 more
core   +1 more source