Results 131 to 140 of about 105,966 (270)

Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation [PDF]

Aberrant cholesterol metabolism causes neurological disease and neurodegeneration, and mitochondria have been linked to perturbed cholesterol homeostasis via the study of pathological mutations in the ATAD3 gene cluster.
Holt, Ian J., Bindoff, Laurence Albert, Park, Yohan, Varhaug, Kristin N., Pérez-Rodríguez, Diego, Knappskog, Per Morten, Pascual-Frías, Nerea, López de Arbina, Amaia, Gegg, Matthew E., Villar-Fernández, Marina, Bredrup, Cecilie, Martí-Carrera, Itxaso, Spinazzola, Antonella, Bruland, Ove, Hasan, Mazahir T., Knappskog, Per-Morten, Fernandez-Checa, Jose, Bindoff, Laurence A., Varhaug, Kristin Nielsen, Sandoval, Abigail, Fernández-Pelayo, Uxoa, Gereñu-Lopetegui, Gorka, García-Ruiz, Carmen, Fernández-Checa, José C., Yoon, Wan Hee, Gil-Bea, Francisco Javier, Muñoz-Oreja, Mikel, de Arbina, Amaia Lopez, Hernández-Eguiazu, Haizea, Hernández, Ixiar, Goicoechea, Leire   +30 more
core   +1 more source

Unanswered Role of Cholesterol Homeostasis in Parkinson’s Disease [PDF]

, 2020
Cholesterol has a key role in neuronal function and alterations in brain cholesterol homeostasis correlate with neurodegeneration. While disruptions in cholesterol homeostasis have been clearly associated with neurodegenerative disorders such as ...
Caria, Inês de Sousa
core  

Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 206-214, April 2025.
Abstract Objective Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Titi Yang, Emi Okada, Maho Todoroki, Siyu Liu, Rukmali Athurupana, Kumie Kataoka, Chiaki Kashino, Takashi Mitsui, Toru Hasegawa, Yasuhiko Kamada, Hisashi Masuyama, Mikiya Nakatsuka   +11 more
wiley   +1 more source

Unraveling the Connection: Cholesterol, Calcium Signaling, and Neurodegeneration

Neuroscience Insights
Cholesterol and calcium play crucial roles as integral structural components and functional signaling entities within the central nervous system. Disruption in cholesterol homeostasis has been linked to Alzheimer’s, Parkinson’s, and Huntington’s Disease ...
Maria Casas, Eamonn J Dickson
doaj   +1 more source

Bifidobacterium animalis BGI‐L99 Ameliorates Polycystic Ovary Syndrome by Modulating the Gut Microbiota‐Bile Acid‐IL‐22 Axis

iMetaMed, EarlyView.
Polycystic ovary syndrome (PCOS) is described as a complex endocrine‐metabolic disorder frequently accompanied by reproductive dysfunction and depression‐like behaviors. During PCOS progression, gut microbiota dysbiosis and systemic bile acid disturbances co‐occur, severely disrupting host immune and metabolic homeostasis. B.
Haoyu Wang, Weixuan Chen, Xiaofang Li, Xiaohong Lu, Tianli Liu, Jiarui Liang, Yajie Wang, Mengzhen Jia, Ruiyu Zhang, Yuzheng Gu, Jielei Zhu, Jiayi Ma, Zhinan Wu, Yiyi Zhong, Haifeng Zhang, Tao Yang, Liang Xiao, Zhigang Liu, Yuanqiang Zou   +18 more
wiley   +1 more source

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease

Antioxidants
Down syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is ...
Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamba   +10 more
doaj   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Cholesterol homeostasis in the brain : importance of 24S-hydroxylation [Elektronisk resurs]

, 1999
Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain.
Lütjohann, D,
core  

Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels

, 2009
Apolipoprotein E (apoE) is a regulator of peripheral cholesterol homeostasis, and the apoE-isoform E4 is a major risk factor for the development of Alzheimer's disease (AD). Accumulating evidence suggests a key role for aberrant cholesterol metabolism in
Paula J. Jansen, van Leuven, Fred, Fred van Leuven, Monique, Monique, Ramaekers, Frans C S, Karin M. Thelen, Thelen, Karin M, Monique Monique, Lütjohann, Dieter, Dieter Lütjohann, Klaus von Bergmann, Frans C.S. Ramaekers, von Bergmann, Klaus, Jansen, Paula J   +13 more
core   +1 more source