Results 41 to 50 of about 19,677 (188)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Concussion and the Sleeping Brain

Sports Medicine - Open
Abstract Background Emerging research has suggested sleep to be a modifier of the trajectory of concussion recovery in adolescent and adult populations. Despite the growing recognition of the relationship between sleep and concussion, the mechanisms and physiological processes governing this association have yet to be ...
Catherine C. Donahue, Jacob E. Resch
openaire   +3 more sources

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Concussion Disrupts Normal Brain White Matter Microstructural Symmetry

Frontiers in Neurology, 2020
Injuries and illnesses can alter the normal bilateral symmetry of the brain, and determining the extent of this disruption may be useful in characterizing the pathology.
Jun Maruta, Jun Maruta, Jun Maruta, Jacob M. Mallott, Gary Sulioti, Gary Sulioti, Jamshid Ghajar, Jamshid Ghajar, Eva M. Palacios, Pratik Mukherjee, Pratik Mukherjee   +10 more
doaj   +1 more source

Recurrent neural network-based acute concussion classifier using raw resting state EEG data

Scientific Reports, 2021
Concussion is a global health concern. Despite its high prevalence, a sound understanding of the mechanisms underlying this type of diffuse brain injury remains elusive.
Karun Thanjavur, Arif Babul, Brandon Foran, Maya Bielecki, Adam Gilchrist, Dionissios T. Hristopulos, Leyla R. Brucar, Naznin Virji-Babul   +7 more
doaj   +1 more source

A Core Head, Neck, and Neuroanatomy Syllabus for Physical Therapy Student Education

Clinical Anatomy, EarlyView.
ABSTRACT Head, neck, and neuroanatomy are essential components of physical therapy education due to their broad clinical applications. Detailed syllabi exist for medical students, yet none have been developed for physical therapy. This study aimed to produce an International Federation of Associations of Anatomists core head, neck, and neuroanatomy ...
Stephanie J. Woodley, Brooke Willoughby, Alexandra L. Webb, Natasha A. M. S. Flack, Laura Y. Whitburn   +4 more
wiley   +1 more source

Prospective evaluation of a seizure detection wearable device for timely interventions in an epilepsy monitoring unit

Epilepsia, EarlyView.
Abstract Objective This study aimed to evaluate the real‐world performance of a wrist‐worn seizure detection device for timely clinical interventions within an epilepsy monitoring unit (EMU). Methods We conducted a prospective observational study involving patients admitted to the EMU at a tertiary care center.
Amirhossein Jahani, Daniel Alejandro Galindo Lazo, Isabel Sarzo Wabi, Oumayma Gharbi, Manon Robert, Juan Pablo Millan, Gianluca D'onofrio, Alexis Robin, Dang K. Nguyen, Elie Bou Assi   +9 more
wiley   +1 more source

Sport-related concussions

Dementia & Neuropsychologia
Traumatic brain injury (TBI) is a major cause of lifelong disability and death worldwide. Sport-related traumatic brain injury is an important public health concern. The purpose of this review was to highlight the importance of sport-related concussions.
Jéssica Natuline Ianof, Fabio Rios Freire, Vanessa Tomé Gonçalves Calado, Juliana Rhein Lacerda, Fernanda Coelho, Silvia Veitzman, Magali Taino Schmidt, Sergio Machado, Bruna Velasques, Pedro Ribeiro, Luis Fernando Hindi Basile, Wellingson Silva Paiva, Robson Amorim, Renato Anghinah   +13 more
doaj   +1 more source

Fast ripple‐delta coupling as an early biomarker for post‐traumatic epileptogenesis in repetitive brain injury

Epilepsia Open, EarlyView.
Abstract Objective Traumatic brain injury (TBI) can induce posttraumatic epilepsy (PTE), but early biomarkers for epileptogenesis are lacking. We aimed to investigate electrographic biomarkers before and during posttraumatic seizure development. Methods We used a repetitive diffuse TBI model in mice with continuous video‐EEG monitoring up to 4½ months ...
Oleksii Shandra, Dzenis Mahmutovic, Biswajit Maharathi, Md Adil Arman, Michael J. Benko, Owen Leitzel, Pritom Kumar Saha, Stefanie Robel   +7 more
wiley   +1 more source

Googling concussion care in the USA: a critical appraisal of online concussion healthcare providers

Concussion, 2017
Aim: To examine the online personnel and practice profiles of concussion healthcare providers in the USA. Methods: We conducted independent, blinded, Google Internet searches for concussion healthcare providers using the terms ‘concussion clinic’ and ...
Michael J Ellis, Lesley Ritchie, Erin Selci, Stephanie Grossi, Samantha Frost, Patrick J McDonald, Kelly Russell   +6 more
doaj   +1 more source