Results 81 to 90 of about 5,117,673 (294)

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

An Assessment of Melatonin’s Therapeutic Value in the Hypoxic-Ischemic Encephalopathy of the Newborn

Frontiers in Synaptic Neuroscience, 2019
Hypoxic-ischemic encephalopathy (HIE) is one of the most frequent causes of brain injury in the newborn. From a pathophysiological standpoint, a complex process takes place at the cellular and tissue level during the development of newborn brain damage ...
Daniel P. Cardinali
doaj   +1 more source

Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration [PDF]

, 2017
Survivors of a traumatic brain injury can deteriorate years later, developing brain atrophy and dementia. Traumatic brain injury triggers chronic microglial activation, but it is unclear whether this is harmful or beneficial.
Henrik Zetterberg, Blennow, Kaj,, Cole, James H, Gunn, Roger N, Jolly, A, Cole, JH, Sara De Simoni, Feeney, C, Blennow, K, Oliver Howes, Gregory Scott, Scott, GPT, Patel, MC, Owen, David R, Matthews, PM, Scott, Gregory, Anthony P Goldstone, Lingford-Hughes, Anne, Zetterberg, Henrik,, Feeney, Claire, Lingford-Hughes, A, James H Cole, Jenkins, PO, Goldstone, Anthony P, Sharp, David J, Amy Jolly, Scott, G, Jolly, Amy, Howes, Oliver, De Simoni, S, Patel, Maneesh C, Howes, O, Owen, DR, Kaj Blennow, Maneesh C Patel, David J Sharp, David R Owen, Paul M Matthews, Roger N Gunn, Jenkins, Peter O, Zetterberg, H, Matthews, Paul M, Peter O Jenkins, Anne Lingford-Hughes, Zetterberg, Henrik, Sharp, DJ, De Simoni, Sara, Cole, James H; id_orcid, Goldstone, AP, Claire Feeney, Blennow, Kaj, Gunn, RN   +51 more
core   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Conceptual approaches to the treatment of neurosurgical pathology (based on examples of chronic subdural hematomas and severe brain contusions)

Клинический разбор в общей медицине
Introduction. General development tendency for modern neurosurgery is characterized by neuroimaging of focal brain damage at an early stage, choice of conceptual approaches to treatment tactics and minimization of operative interventions themselves ...
Leonid B. Likhterman, Vladimir A. Okhlopkov, Alexander D. Kravchuk, Boleslav L. Lichterman   +3 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition

Journal of Pregnancy, 2011
Cerebral palsy is a major neonatal handicap with unknown aetiology. There is evidence that prenatal brain injury is the leading cause of CP. Severe placental pathology accounts for a high percentage of cases.
Begoña Pellicer, Sonia Herraiz, Antonio Leal, Carlos Simón, Antonio Pellicer   +4 more
doaj   +1 more source

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina, Dono, Rosanna, Schindowski, Katharina, Krause, Sonja, Bohlen und Halbach, Oliver von, Schwaninger, Markus, Unsicker, Klaus   +6 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Emotion recognition in chronic treatment-resistant depression : before and after neurosurgical treatment [PDF]

, 2013
The neuroanatomical structures underlying Major Depressive Disorder (MDD) are not fully understood. Invasive treatment options now exist that target the brain structures associated with MDD.
Grant, Frazer Alexander Lockhart
core   +2 more sources