Results 61 to 70 of about 353,130 (267)

Altered Expression of ZnT10 in Alzheimer's Disease Brain [PDF]

, 2013
There is an increasing body of evidence suggesting that metal homeostasis is dysregulated in the pathology of Alzheimer's disease (AD). Although expression levels of several transporters belonging the SLC30 family, which comprises predominantly zinc ...
Ruth A. Valentine (208371), Paul A Adlard, Ruth A. Valentine, Helen J. Bosomworth (417547), Ford, D, Bosomworth, Helen, Adlard, Paul, Dianne Ford, Valentine, Ruth, Paul A. Adlard, Paul A. Adlard (31148), Dianne Ford (174115), Bosomworth, HJ, Helen J Bosomworth, Ruth A Valentine, Skoulakis, Efthimios, Helen J. Bosomworth, Adlard, PA, Valentine, RA, Ford, Dianne   +19 more
core   +1 more source

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

Frontiers in Pharmacology
Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a more advanced and irreversible state of liver damage.
Cenlu Xu, Haoran Tai, Yanan Chu, Ye Liu, Jiacheng He, Yiran Wang, Bingyin Su, Shurong Li   +7 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Stress and neurochemical changes associated with chronic alcohol administration [PDF]

, 2001
: There is considerable recent experimental evidence that suggests that stress plays a major role in the development of dependence on drugs of abuse, but the potential mechanisms involved are not yet fully understood.
O'Callaghan, Matthew Joseph
core  

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina, Dono, Rosanna, Schindowski, Katharina, Krause, Sonja, Bohlen und Halbach, Oliver von, Schwaninger, Markus, Unsicker, Klaus   +6 more
core   +1 more source

Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition

Dementia & Neuropsychologia
Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output ...
Jamary Oliveira-Filho
doaj   +1 more source

Sirtuins and neuronal DNA damage under experimental chronic cerebral hypoperfusion

Patologìâ, 2019
Chronic brain hypoperfusion (ChCH) is a risk factor for central nervous system (CNS) diseases, such as chronic brain ischemia, degenerative diseases, and others, in this connection, the study of its pathophysiological mechanisms is an actual problem ...
O. Yu. Harmatina, Т. Yu. Voznesenska, N. H. Hrushka, О. А. Kondratska, А. H. Portnychenko   +4 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Space Perception in Chronic Schizophrenia and Brain-Damage

, 1964
The hypothesis that chronic schizophrenia may be a form of organic brain damage was tested, using a reliable spatial perceptual test with two groups: chronic schizophrenics and organic brain-damaged Ss.
Paul G. Daston
core   +1 more source

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]

, 2012
Peer ...
Maetzler, Walter, Berg, Daniela, Teismann, Peter, Mounsey, Ross Brian, Vukovic, Zvonimir, Synofzik, Matthis, Mustafa, Sarah, Itohara, Shigeyoshi, Sathe, Kinnari, Schulte, Claudia, Martin, Heather Louise, Lang, Johannes, Fleckenstein, Corinna   +12 more
core   +1 more source