Results 61 to 70 of about 4,854,049 (293)

Sirtuins and neuronal DNA damage under experimental chronic cerebral hypoperfusion

Patologìâ, 2019
Chronic brain hypoperfusion (ChCH) is a risk factor for central nervous system (CNS) diseases, such as chronic brain ischemia, degenerative diseases, and others, in this connection, the study of its pathophysiological mechanisms is an actual problem ...
O. Yu. Harmatina, Т. Yu. Voznesenska, N. H. Hrushka, О. А. Kondratska, А. H. Portnychenko   +4 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition

Dementia & Neuropsychologia
Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output ...
Jamary Oliveira-Filho
doaj   +1 more source

Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice

NeuroImage: Clinical, 2018
Due to the heterogeneous pathology of traumatic brain injury (TBI), the exact mechanism of how initial brain damage leads to chronic inflammation and its effects on the whole brain remain unclear.
Sanae Hosomi, Tadashi Watabe, Yuki Mori, Yoshihisa Koyama, Soichiro Adachi, Namiko Hoshi, Mitsuo Ohnishi, Hiroshi Ogura, Yoshichika Yoshioka, Jun Hatazawa, Toshihide Yamashita, Takeshi Shimazu   +11 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Hypertensive target organ damage in Ghanaian civil servants with hypertension. [PDF]

, 2009
BACKGROUND: Low levels of detection, treatment and control of hypertension have repeatedly been reported from sub Saharan Africa, potentially increasing the likelihood of target organ damage.
David A Leon, Leon, David A, Smeeth, Liam, Juliet Addo, Smeeth Liam, Addo Juliet, Addo, Juliet, Liam Smeeth, Leon David A.   +8 more
core   +1 more source

Gastrostomias e fundoplicaturas: estudo retrospectivo de 5 anos em pacientes pediátricos no Hospital Municipal Jesus/RJ

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Analisar o quadro clínico, morbi-mortalidade e resultados da fundoplicatura gastroesofágica em crianças, com ênfase em portadores de encefalopatias crônicas.
Lisieux Eyer de Jesus, Paulo César Costa Monteiro, Renata Restay Siqueira, Elisiane Bezerra Marinho, Pedro Augusto Vital Nogueira   +4 more
doaj   +1 more source

Necroptosis and microglia activation after chronic ischemic brain injury in mice

European Journal of Inflammation, 2017
Microglia, which are the resident macrophages and the first line of defense in the brain, can be activated within hours and migrate toward the injury sites after acute and chronic ischemic brain injury.
Shehong Zhang, Yuyang Wang, Hongyu Xie, Qing Yu, Junfa Wu, Yi Wu, Yulian Zhu   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source