Results 51 to 60 of about 4,854,049 (293)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury

Antioxidants
Traumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage to brain tissue.
Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska   +3 more
doaj   +1 more source

Evaluation of Cerebral Blood Flow Using Arterial Spin Labeling in Patients with Chronic Kidney Disease

대한영상의학회지, 2020
Purpose This study aimed to compare the brain perfusion status of patients with chronic kidney disease to a normal control group to identify any significant differences.
Se Won Oh, Samel Park, Nam-jun Cho, Hyo-Wook Gil, Eun Young Lee, Hyung Geun Oh, Sung-Tae Park   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cognitive impairment, dizziness, and unsteadiness in hypertensive patients

Неврология, нейропсихиатрия, психосоматика, 2020
Hypertension is a widespread disease related to modifiable vascular risk factors for stroke and chronic cerebrovascular diseases. The pathogenetic basis of brain damage in hypertension is cerebral microangiopathy that leads to vascular cognitive ...
L. M. Antonenko, N. V. Vakhnina, D. O. Gromova   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice

Frontiers in Pharmacology
Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a more advanced and irreversible state of liver damage.
Cenlu Xu, Haoran Tai, Yanan Chu, Ye Liu, Jiacheng He, Yiran Wang, Bingyin Su, Shurong Li   +7 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

What went wrong? The flawed concept of cerebrospinal venous insufficiency [PDF]

, 2013
In 2006, Zamboni reintroduced the concept that chronic impaired venous outflow of the central nervous system is associated with multiple sclerosis (MS), coining the term of chronic cerebrospinal venous insufficiency ('CCSVI'). The diagnosis of 'CCSVI' is
Schreiber, SJ, Doepp, F, Schreiber, S.J., Paul, F., van Oosten, BW, Wattjes, MP, Paul, F, Valdueza, JM, Doepp, F., Wattjes, M.P., Schmierer, K, Valdueza, J.M., Schmierer, K., van Oosten, B.W.   +13 more
core   +1 more source

Indoxyl Sulfate-Mediated Blood–Brain Barrier Damage in Chronic Kidney Disease

Toxins
Chronic kidney disease is associated with neurovascular complications including cognitive impairment, potentially involving blood–brain barrier (BBB) impairment.
Leah Hernandez, Camillo Tancredi Strizzi, Miriam Rosina, Angelina Schwarz, Nina Kronqvist, Samsul Arefin, Peter Stenvinkel, Karolina Kublickiene   +7 more
doaj   +1 more source