Results 31 to 40 of about 353,130 (267)

Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells

Brain Sciences
Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities.
Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song   +3 more
doaj   +1 more source

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

Scientific Reports, 2017
The widespread use of combinational antiretroviral therapies (cART) in developed countries has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost universally fatal disease to a chronic infection for the majority of ...
Alex M. Dickens, Seung Wan Yoo, Alfred C. Chin, Jiadi Xu, Tory P. Johnson, Amanda L. Trout, Kurt F. Hauser, Norman J. Haughey   +7 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

, 2012
Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these ...
Shtaya, Anan, Taylor, Matthew, Hamilton, Derek A., Gray, William Peter, Barkas, Lisa, Redhead, Edward, Gray, William P.   +6 more
core   +1 more source

The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke [PDF]

, 2012
Hemispatial neglect following right-hemisphere stroke is a common and disabling disorder, for which there is currently no effective pharmacological treatment. Dopamine agonists have been shown to play a role in selective attention and working memory, two
Kulinskaya, Elena, Singh-Curry, Victoria, Nair, Ajoy, Singh-Curry, V, Ward, N, Ward, Nick, Mah, Y-H, Mah, Yee-Haur, Greenwood, Richard, Cohen, D, Simister, R, Hadji-Michael, M, Greenwood, R, Cohen, David, Mah, YH, Machner, Bjoern, Husain, M, Malhotra, Paresh, Kulinskaya, E, Gorgoraptis, N, Gorgoraptis, Nikos, Machner, B, Malhotra, P, Nair, A, Hadji-Michael, Maria, Simister, Robert, Husain, Masud   +26 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Chronic Hypertension Aggravates Heat Stress-Induced Brain Damage: Possible Neuroprotection by Cerebrolysin

, 2009
Whole body hyperthermia (WBH) aggravates brain edema formation and cell damage in chronic hypertensive rats compared with normotensive animals. In this investigation, we examined the influence of cerebrolysin on WBH-induced edema formation and brain ...
Dafin Fior Muresanu, Zimmermann-Meinzingen, Sibilla, Muresanu, Dafin Fior, Sibilla Zimmermann-Meinzingen, Sharma, Hari Shanker,, Hari Shanker Sharma   +5 more
core   +1 more source

Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death. [PDF]

PLoS ONE, 2013
The Tyro3, Axl and Mertk (TAM) triply knockout (TKO) mice exhibit systemic autoimmune diseases, with characteristics of increased proinflammatory cytokine production, autoantibody deposition and autoreactive lymphocyte infiltration into a variety of ...
Qiutang Li, Qingjun Lu, Huayi Lu, Shifu Tian, Qingxian Lu   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source