Results 101 to 110 of about 18,442,102 (269)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Correction to: SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/bioconductor‑powered RNA‑seq analyses

BMC Bioinformatics, 2021
Nicholas J. Eagles, Emily E. Burke, Jacob Leonard, Brianna K. Barry, Joshua M. Stolz, Louise Huuki, BaDoi N. Phan, Violeta Larios Serrato, Everardo Gutiérrez-Millán, Israel Aguilar-Ordoñez, Andrew E. Jaffe, Leonardo Collado-Torres   +11 more
doaj   +1 more source

A comprehensive EEG dataset for investigating visual touch perception

Scientific Data
Visual touch perception is fundamental to body awareness and social bonding, helping us perceive ourselves and connect with others. However, understanding its neural basis has been limited by a lack of comprehensive public datasets.
Sophie Smit, Almudena Ramírez-Haro, Manuel Varlet, Denise Moerel, Genevieve L. Quek, Tijl Grootswagers   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Chronic oral administration of ibrutinib prevents long-term memory deficits and reduces AD pathology and neuroinflammatory responses in a mouse model of AD

Molecular Brain
We previously demonstrated that ibrutinib has therapeutic efficacy against AD pathologies when injected intraperitoneally at a lower dosage (10 mg/kg, daily for 2 weeks) or orally at a higher dosage (30 mg/kg, daily for 1 month) in AD mice models ...
Hyun-ju Lee, Sora Kang, Yoo Joo Jeong, Jin-Hee Park, Jeong-Woo Hwang, Chan-Hu Gu, Tae-Mi Jung, Seokjun Oh, Ji-Yeong Jang, Hyang-Sook Hoe   +9 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Translational Psychiatry
Sustained attention, the ability to focus on a stimulus or task over extended periods, is crucial for higher level cognition, and is impaired across multiple neuropsychiatric and neurodevelopmental disorders, including attention-deficit/hyperactivity ...
Jorge Miranda-Barrientos, Suhaas Adiraju, Jason J. Rehg, Michael S. Totty, Henry L. Hallock, Ye Li, Gregory V. Carr, Keri Martinowich   +7 more
doaj   +1 more source

Exploring the role of brain oscillations in speech perception in noise: Intelligibility of isochronously retimed speech

Frontiers in Human Neuroscience, 2016
A growing body of evidence shows that brain oscillations track speech. This mechanism is thought to maximise processing efficiency by allocating resources to important speech information, effectively parsing speech into units of appropriate granularity ...
Vincent Aubanel, Chris Davis, Jeesun Kim
doaj   +1 more source

IDB News: Vol. 3, no. 1, February 1976

, 1976
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Progress Report (2014-2015) of the MDB Working Group on Sustainable Transport [PDF]

, 2015
1. In the third year of the Multilateral Development Banks¿1 (MDBs) Joint Statement of 2012, our eight MDBs are on target to meet the goal of the Commitment to Sustainable Transport (hereafter the Rio+20 Commitment) to provide more than $175 billion of ...
Inter-American Development Bank
core   +1 more source