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Metabolic syndrome: a brain disease
Canadian Journal of Physiology and Pharmacology, 2012Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of ω-6 fatty acids, and low levels of ω-3 fatty acids and ...
Ram B, Singh +7 more
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Brain Iron Metabolism and CNS Diseases
2019Iron is the most abundant trace element in the human body. It is well known that iron is an important component of hemoglobin involved in the transport of oxygen. As a component of various enzymes, it participates in the tricarboxylic acid cycle and oxidative phosphorylation.
Anand, Thirupathi, Yan-Zhong, Chang
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The Metabolic Syndrome: A Brain Disease?
Journal of Neuroendocrinology, 2006SummaryThe incidence of obesity with, as consequence, a rise in associated diseases such as diabetes, hypertension and dyslipidemia − the metabolic syndrome − is reaching epidemic proportions in industrialized countries. Here, we provide a hypothesis that the biological clock which normally prepares us each morning for the coming activity period is ...
Buijs, R.M., Kreier, F.
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CARBOHYDRATE METABOLISM IN BRAIN DISEASE
A.M.A. Archives of Neurology & Psychiatry, 1954CLAUDE BERNARD'S experiments of a century ago stimulated interest in the relation between functions of the brain and glucose metabolism. Some authors, including Jelliffe,1have since reported metabolic abnormalities in multiple sclerosis; the reported changes consisted in a low fasting serum inorganic phosphorus3and a high fasting serum cholesterol ...
D H, HENNEMAN +3 more
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Brain insulin signalling in metabolic homeostasis and disease
Nature Reviews Endocrinology, 2021Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence ...
Thomas Scherer +2 more
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Brain cholesterol metabolism and neurologic disease
Neurology, 2008ABC= : ATP binding cassette; ABCA1= : ABC transporter protein family member A1; AD= : Alzheimer disease; apoE= : apolipoprotein E; APP= : amyloid precursor protein; ATP= : adenosine triphosphate; CoA= : coenzyme A; CYP= : cytochrome P; 7-DHC= : 7-dehydrocholesterol; ER= : endoplasmic reticulum; HD= : Huntington disease;
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Brain Iron Metabolism Dysfunction in Parkinson’s Disease
Molecular Neurobiology, 2016Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's disease, and Huntington's disease. Understanding how iron accumulates in the substantia nigra (SN) and why it specifically targets dopaminergic (DAergic) neurons is ...
Hong, Jiang +3 more
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