Results 221 to 230 of about 338,090 (265)

Carbohydrate Metabolism in Brain Disease

A.M.A. Archives of Internal Medicine, 1957
Earlier work has shown that patients with schizophrenic, manic-depressive, and involutional psychoses have a disorder of carbohydrate metabolism 1 that is indistinguishable from one exhibited by nonpsychotic patients with a chronic brain disease, i. e., multiple sclerosis.
M D, ALTSCHULE, P D, HOLLIDAY, M, VICTOR
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Altered arginine metabolism in Alzheimer's disease brains

Neurobiology of Aging, 2014
L-arginine is a semi-essential amino acid with a number of bioactive metabolites. Accumulating evidence suggests the implication of altered arginine metabolism in the pathogenesis of Alzheimer's disease (AD). The present study systematically compared the metabolic profile of L-arginine in the superior frontal gyrus, hippocampus, and cerebellum from AD (
Ping Liu, Michael S. Fleete, Yu Jing, Nicola D. Collie, Maurice A. Curtis, Henry J. Waldvogel, Richard L.M. Faull, Wickliffe C. Abraham, Hu Zhang   +8 more
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Typical cerebral metabolic patterns in neurodegenerative brain diseases

Movement Disorders, 2010
AbstractThe differential diagnosis of neurodegenerative brain diseases on clinical grounds is difficult, especially at an early disease stage. Several studies have found specific regional differences of brain metabolism applying [18F]‐fluoro‐deoxyglucose positron emission tomography (FDG‐PET), suggesting that this method can assist in early ...
Teune, Laura K., Bartels, Anna L., de Jong, Bauke M., Willemsen, Antoon T. M., Eshuis, Silvia A., de Vries, Jeroen J., van Oostrom, Joost C. H., Leenders, Klaus L.   +7 more
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The Alzheimer’s Disease-Related Glucose Metabolic Brain Pattern

Current Alzheimer Research, 2014
[(18)F]fluorodeoxyglucose (FDG) PET imaging of the brain can be used to assist in the differential diagnosis of dementia. Group differences in glucose uptake between patients with dementia and controls are well-known. However, a multivariate analysis technique called scaled subprofile model, principal component analysis (SSM/PCA) aiming at identifying ...
Teune, Laura K., Strijkert, Fijanne, Renken, Remco J., Izaks, Gerbrand J., de Vries, Jeroen J., Segbers, Marcel, Roerdink, Jos B. T. M., Dierckx, Rudi A. J. O., Leenders, Klaus L.   +8 more
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Validation of parkinsonian disease‐related metabolic brain patterns

Movement Disorders, 2013
ABSTRACTBackgroundThe objective of this study was to validate disease‐related metabolic brain patterns for Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.MethodsThe study included 20 patients with Parkinson's disease, 21 with multiple system atrophy, and 17 with progressive supranuclear palsy, all of whom had undergone
Teune, Laura K., Renken, Remco J., Mudali, Deborah, De Jong, Bauke M., Dierckx, Rudi A., Roerdink, Jos B.T.M., Leenders, Klaus L.   +6 more
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Carbohydrate Metabolism in Brain Disease

A.M.A. Archives of Internal Medicine, 1960
Introduction Earlier communications from this laboratory reported abnormalities in carbohydrate metabolism in various psychotic states. 1,2 Among the most important of the changes noted in patients was an excessive rise in lactate and pyruvate after ingestion of glucose or fructose; similar changes in α-ketoglutarate and citrate have also been ...
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Degenerative and Metabolic Brain Diseases

2015
Neurodegenerative diseases are rare in childhood. Most of them result from disturbances in the metabolism of energy, lipids, amino acids, or metals. Symptoms may not appear before childhood or adolescence, but some are fatal in utero or in the neonatal period; they form the core of this overview.
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Brain metabolic signatures across the Alzheimer’s disease spectrum

European Journal of Nuclear Medicine and Molecular Imaging, 2019
Given the challenges posed by the clinical diagnosis of atypical Alzheimer's disease (AD) variants and the limited imaging evidence available in the prodromal phases of atypical AD, we assessed brain hypometabolism patterns at the single-subject level in the AD variants spectrum. Specifically, we tested the accuracy of [18F]FDG-PET brain hypometabolism,
Sala, Arianna, Caprioglio, Camilla, Santangelo, Roberto, Vanoli, Emilia Giovanna, Iannaccone, Sandro, Magnani, Giuseppe, Perani, Daniela   +6 more
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Tocopherol in brain metabolism and disease: A review

Metabolic Brain Disease, 1987
All aerobic cells form free radicals. During respiration, univalent reactions of oxygen are preferred, producing superoxide radicals (O~-), hydrogen peroxide (H202), and hydroxyl radicals (OH'). Additional OH" radicals and singlet oxygen (102) form following reactions with metal catalysts.
P, Divakaran, R C, Wiggins
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Metabolic Diseases of the Brain

2013
Metabolic disorders are responsible for brain diseases causing abnormal growth and development. They are caused by genetically determined enzymatic defects in the metabolic pathways producing structurally defective protein. Enzymes are contained in the cellular organelles, and metabolic brain diseases can be categorized according to the most frequently
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