Results 211 to 220 of about 358,246 (264)

Hypothesis of the Causal Mechanisms Between Gut Microbiota and Neurodegenerative Diseases: An Elucidation from Evolutionary Perspective and Metabolic Consideration. [PDF]

Metabolites
Tang G, Guo L, Liu Z, Quan Y.
europepmc   +1 more source

Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1. [PDF]

Expert Rev Clin Pharmacol
Maiese K.
europepmc   +1 more source

PARP inhibitors target cellular energy metabolism: Mechanisms of action and clinical implications. [PDF]

Transl Oncol
Li J, Mu D, Li J, Lan M, Wu W, Zhang S, Dai Y.   +6 more
europepmc   +1 more source

Exploring <i>In situ</i> neuroprotective mechanisms of nicotine in an MPTP-Induced Parkinson's disease rat model using spatial metabolomics. [PDF]

Front Cell Dev Biol
Xu L, Li Q, Zhu M, Wang G, Wang H, Han S, Fu Y, Chen H, Hou H.   +8 more
europepmc   +1 more source

Mechanistic Insights into Dihydromyricetin: Redox Modulation and Kinase-Mediated Control of Disease Pathogenesis. [PDF]

Int J Mol Sci
Fabiyi OA, Ogundele AV, Ibrahim SO, Ibrahim H, Silva HH.   +4 more
europepmc   +1 more source

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Brain insulin signalling in metabolic homeostasis and disease

Nature Reviews Endocrinology, 2021
Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence ...
Thomas Scherer, Kenichi Sakamoto, Christoph Buettner   +2 more
exaly   +3 more sources

Metabolic syndrome: a brain disease

Canadian Journal of Physiology and Pharmacology, 2012
Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of ω-6 fatty acids, and low levels of ω-3 fatty acids and ...
Ram B, Singh, Siddharth, Gupta, Parinita, Dherange, Fabien, De Meester, Agnieszka, Wilczynska, Shaan E, Alam, Daniel, Pella, Douglas W, Wilson   +7 more
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The Metabolic Syndrome: A Brain Disease?

Journal of Neuroendocrinology, 2006
SummaryThe incidence of obesity with, as consequence, a rise in associated diseases such as diabetes, hypertension and dyslipidemia − the metabolic syndrome − is reaching epidemic proportions in industrialized countries. Here, we provide a hypothesis that the biological clock which normally prepares us each morning for the coming activity period is ...
Buijs, R.M., Kreier, F.
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Tocopherol in brain metabolism and disease: A review

Metabolic Brain Disease, 1987
All aerobic cells form free radicals. During respiration, univalent reactions of oxygen are preferred, producing superoxide radicals (O~-), hydrogen peroxide (H202), and hydroxyl radicals (OH'). Additional OH" radicals and singlet oxygen (102) form following reactions with metal catalysts.
P, Divakaran, R C, Wiggins
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