Results 61 to 70 of about 358,246 (264)

Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults

Frontiers in Endocrinology
ObjectiveThis study evaluated the performance of the SiJoy GS1 Continuous Glucose Monitor (CGM) system by analyzing the time lag between plasma glucose (PG) and CGM measurements during an Oral Glucose Tolerance Test (OGTT) in healthy adults.
Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Xianbao Shi, Feng Xu, Feng Xu, Lin Chen, Lin Chen, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xiaolong Jin, Xiaolong Jin, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu   +30 more
doaj   +1 more source

Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Computational and Structural Biotechnology Journal, 2020
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported.
Qiaoying Jiang, Hangying Xu, Junjie Yan, Qingqing Xu, Yafei Zheng, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng   +8 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science
Brain metabolism is uniquely regulated, and alterations in its metabolic networks often serve as critical drivers of the onset and progression of brain diseases.
Jingyi Zhou, Chen Jiang
doaj   +1 more source

Hemoglobin is associated with BMDs and risk of the 10-year probability of fractures in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
PurposeThis study aimed to investigate the associations between hemoglobin (HGB) levels and bone mineral density (BMD) and fracture risk in type 2 diabetes mellitus(T2DM) population of different ages.
Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Na Xu, Na Xu, Na Xu, Na Xu, Na Xu, Na Xu, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Lei Zhu, Yan-man Zhou, Yan-man Zhou, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu   +73 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Research progress on the role and mechanism of the glymphatic system in the occurrence and development of brain diseases

Guangxi Yike Daxue xuebao
Biomedical research in recent years has revealed a new mechanism by which the brain can effectively remove metabolic waste generated by the neural tissue through the glymphatic system.
CHANG Junlei, FENG Ziying
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source