Results 91 to 100 of about 14,759,557 (296)

Factors associated with adverse outcomes following perioperative stroke after noncardiac surgery

Journal of Stroke and Cerebrovascular Diseases
Background: Perioperative stroke is associated with high rates of adverse outcomes. Our objective was to identify factors associated with 30-day mortality, adverse discharge, and length of hospital stay following perioperative stroke among noncardiac ...
Jaycee R. Farmer, MSc, Jason M. Sutherland, PhD, Thalia S. Field, MD, FRCPC, Daniel I. McIsaac, MD, FRCPC, Adrian W. Gelb, MD, FRCPC, Lily W. Zhou, MD, FRCPC, Terri Sun, MD, FRCPC, Stephan K.W. Schwarz, MD, PhD, FRCPC, Alana M. Flexman, MD, MBA, FRCPC   +8 more
doaj   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Targeting aging hallmarks in brain health within the framework of preventive medicine: mechanistic insights into naringenin’s role in longevity, synaptic function, and cellular homeostasis

Frontiers in Nutrition
Aging is the primary driver of neurodegenerative vulnerability and functional decline in the brain. This narrative review synthesizes preclinical in vitro and in vivo evidence on naringenin, a citrus-derived flavonoid with pleiotropic effects on aging ...
Yong Zhi, Shanshan Xie, Yanting Sun
doaj   +1 more source

Systemic determinants of brain health in ageing

Preservation of brain health is a worldwide priority. The traditional view is that the major threats to the ageing brain lie within the brain itself.
Gottesman, Rebecca F, Parikh, Neal S, Smith, Eric E, Gao, Virginia, Biessels, Geert Jan, Iadecola, Costantino, Liesz, Arthur   +6 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Acute blood biomarker responses to consensual sexual choking/strangulation in young adult women: a randomized crossover study

Frontiers in Global Women's Health
IntroductionSexual strangulation, commonly referred to as “choking”, has become increasingly common among young adults, yet its neurobiological consequences remain poorly understood.
Sage H. Sweeney, Grace O. Recht, Giselle Lima-Cooper, Dibyadyuti Datta, Claire V. Buddenbaum, Harper Day, Bella Buehler, Megan E. Huibregtse, Megan E. Huibregtse, Debby Herbenick, Debby Herbenick, Keisuke Kawata, Keisuke Kawata, Keisuke Kawata   +13 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Prevalence of traumatic brain injury amongst children admitted to hospital in one health district : a population-based study [PDF]

There is a dearth of information regarding the prevalence of brain injury, serious enough to require hospital admission, amongst children in the United Kingdom.
Magnay, Andrew R., Hawley, Carol, Ward, Anthony B., Long, Julie, Owen, David   +4 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source