Results 101 to 110 of about 14,759,557 (296)

Saccade reaction test for the assessment of cognitive readiness

Frontiers in Neurology
BackgroundCognitive performance such as rapidly reacting to a target or making correct decisions can directly impact task effectiveness in military, emergency, or athletic settings. Saccades are rapid changes in gaze that support recognition and analysis
Jun Maruta, Jun Maruta, Jamshid Ghajar
doaj   +1 more source

Eight questions about brain drain [PDF]

High-skilled emigration is an emotive issue that in popular discourse is often referred to as brain drain, conjuring images of extremely negative impacts on developing countries. Recent discussions of brain gain, diaspora effects, and other advantages of
Gibson, John, McKenzie, David
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Refugee and migrant health system review: challenges and opportunities for long-term health system strengthening in Czechia

x, 43 p.This report presents the findings of a joint review conducted by the World Health Organization and the Ministry of Health of Czechia to assess the health system response to the large-scale arrival of refugees from Ukraine following the Russian ...
World Health Organization
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Toward a “green” brain health agenda: establishing short- and long-term goals for the field of neurology in a changing climate

Frontiers in Neurology
The global burden of neurological disease is rising amid an aging population and accelerating climate change, yet environmental determinants of brain health remain underrecognized within neurology. Climate-related factors—including air pollution, extreme
Esme D. Trahair, Esme D. Trahair, Trisha Dalapati, Danelle Levinson, Danelle Levinson, Alexandra R. Linares, Aaron Reuben, Aaron Reuben, Richard Bedlack   +8 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Acute effects of physical activity breaking up sedentary behavior on cognitive function, biological mechanisms, and practical recommendations: a systematic review

Frontiers in Psychology
IntroductionSedentary behavior threatens cognitive health, yet evidence on the effects of physical activity interruptions is inconsistent. This systematic review synthesizes existing findings and clarifies key sources of heterogeneity. It aims to provide
Yanqi Li, Yang Jiang, Xinxiao Yin, Yanping Song, Na Yao, Zhen Shen, Qigang Chen   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source