TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]
, 2017 Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert +12 more
core +1 more source
An Updated Overview of MRI Injuries in Neonatal Encephalopathy: LyTONEPAL Cohort
Children, 2022 Background: Brain magnetic resonance imaging (MRI) is a key tool for the prognostication of encephalic newborns in the context of hypoxic−ischemic events. The purpose of this study was to finely characterize brain injuries in this context.
Jonathan Beck +7 more
doaj +1 more source
A Generic Trauma Severity Computer Method Applied to Pedestrian Collisions [PDF]
arXiv, 2020 In the real world, the severity of traumatic injuries are measured using the Abbreviated Injury Scale (AIS). However the AIS scale cannot currently be computed by using finite element human computer models, which calculate a maximum principal strains (MPS). Further, MPS only establishes a threshold above which a serious or fatal injury occurs. In order
arxiv
Working toward exposure thresholds for blast-induced traumatic brain injury: thoracic and acceleration mechanisms [PDF]
Neuroimage. 2011 Jan;54 Suppl 1:S55-61, 2011 Research in blast-induced lung injury resulted in exposure thresholds that are useful in understanding and protecting humans from such injury. Because traumatic brain injury (TBI) due to blast exposure has become a prominent medical and military problem, similar thresholds should be identified that can put available research results in context and ...
arxiv +1 more source
Brain Energetics, Mitochondria, and Traumatic Brain Injury [PDF]
arXiv, 2019 We review current thinking about, and draw connections between, brain energetics and metabolism, mitochondria and traumatic brain injury. In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for mechanisms and pathways based on optimal energetic decisions.
arxiv
Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury [PDF]
arXiv, 2022 Traumatic brain injury is a global public health problem associated with chronic neurological complications and long-term disability. Biomarkers that map onto the underlying brain pathology driving these complications are urgently needed to identify individuals at risk for poor recovery and to inform design of clinical trials of neuroprotective ...
arxiv
Epidemiology of cranial cerebral trauma with alcoholic intoxication, in Lvov
Ukrainian Neurosurgical Journal, 2006 In the course of conducted research, the sufficient percentage of brain injuries (BI), arising from the strong alcohol intoxication (12,1% of the total brain injuries amount), sufficient preponderance of men and increasing of the brain ...
V. N. Shevaga, L. R. Chmihl
doaj +1 more source
Multi-directional dynamic model for traumatic brain injury detection [PDF]
arXiv, 2018 Traumatic brain injury (TBI) is a complex injury that is hard to predict and diagnose, with many studies focused on associating head kinematics to brain injury risk. Recently, there has been a push towards using computationally expensive finite element (FE) models of the brain to create tissue deformation metrics of brain injury. Here, we developed a 3
arxiv
Therapeutic Hypothermia in Traumatic Brain injury; Review of History, Pathophysiology and Current Studies [PDF]
Korean Journal of Critical Care Medicine, 2015 The fact that therapeutic hypothermia (TH) has lowered intracranial pressure and protected brain in severe traumatic brain injury (TBI) is well known throughout past sources and experimental data.
Do-Keun Kim, Dong-Keun Hyun
doaj +1 more source
Differential detection of impact site versus rotational site injury by magnetic resonance imaging and microglial morphology in an unrestrained mild closed head injury model. [PDF]
, 2016 Seventy-five percent of all traumatic brain injuries are mild and do not cause readily visible abnormalities on routine medical imaging making it difficult to predict which individuals will develop unwanted clinical sequelae. Microglia are brain-resident
Carson, Monica J +4 more
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