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Scientific Reports, 2023 Traumatic brain injury (TBI) affects how the brain functions in the short and long term. Resulting patient outcomes across physical, cognitive, and psychological domains are complex and often difficult to predict.
Andrew Tritt +9 more
doaj +1 more source
Diverging volumetric trajectories following pediatric traumatic brain injury. [PDF]
, 2017 Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development.
Asarnow, Robert F +10 more
core +3 more sources
Recent advances in traumatic brain injury
Journal of Neurology, 2019 Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge.
Abdelhakim Khellaf, D. Khan, A. Helmy
semanticscholar +1 more source
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
BiomedicinesArtificial intelligence (AI) systems have emerged as promising tools for rapidly identifying patterns in large amounts of healthcare data to help guide clinical decision making, as well as to assist with medical education and the planning of research ...
Kryshawna Beard +5 more
doaj +1 more source
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Nature Communications, 2019 Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and ...
Ashley C. Bolte +12 more
semanticscholar +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
Scientific Reports, 2021 Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood.
Timothy J. Kopper +4 more
doaj +1 more source
Exploring the Production of Extracellular Matrix by Astrocytes in Response to Mimetic Traumatic Brain Injury [PDF]
, 2016 Following injury to the central nervous system, extracellular modulations are apparent at the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response
Walker, Addison
core +2 more sources
Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury*
Critical Care Medicine, 2019 Objectives: Traumatic brain injury triggers multiple cell death pathways, possibly including ferroptosis—a recently described cell death pathway that results from accumulation of 15-lipoxygenase–mediated lipid oxidation products, specifically oxidized ...
Elizabeth M. Kenny +10 more
semanticscholar +1 more source