Results 51 to 60 of about 1,427,435 (334)

Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning

Scientific Reports, 2023
Traumatic brain injury (TBI) affects how the brain functions in the short and long term. Resulting patient outcomes across physical, cognitive, and psychological domains are complex and often difficult to predict.
Andrew Tritt, John K. Yue, Adam R. Ferguson, Abel Torres Espin, Lindsay D. Nelson, Esther L. Yuh, Amy J. Markowitz, Geoffrey T. Manley, Kristofer E. Bouchard, the TRACK-TBI Investigators   +9 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation

Scientific Reports, 2021
Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood.
Timothy J. Kopper, Bei Zhang, William M. Bailey, Kara E. Bethel, John C. Gensel   +4 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Potential Applications and Ethical Considerations for Artificial Intelligence in Traumatic Brain Injury Management

Biomedicines
Artificial intelligence (AI) systems have emerged as promising tools for rapidly identifying patterns in large amounts of healthcare data to help guide clinical decision making, as well as to assist with medical education and the planning of research ...
Kryshawna Beard, Ashley M. Pennington, Amina K. Gauff, Kelsey Mitchell, Johanna Smith, Donald W. Marion   +5 more
doaj   +1 more source

Diverging volumetric trajectories following pediatric traumatic brain injury. [PDF]

, 2017
Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development.
Asarnow, Robert F, Babbitt, Christopher, Babikian, Talin, Dennis, Emily L, Faskowitz, Joshua, Giza, Christopher C, Jahanshad, Neda, Johnson, Jeffrey, Mink, Richard, Rashid, Faisal, Thompson, Paul M   +10 more
core   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Acceptance and commitment therapy delivered in a dyad after a severe traumatic brain injury: a feasibility study [PDF]

, 2018
Objective: There is a high prevalence of complex psychological distress after a traumatic brain injury but limited evidence of effective interventions.
Ciarrochi, Joseph V., Deane, Frank P., McLeod, Hamish J., Simpson, Grahame K., Whiting, Diane L.   +4 more
core   +1 more source

Traumatic brain injury [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
There is an increasing incidence of military traumatic brain injury (TBI), and similar injuries are seen in civilians in war zones or terrorist incidents. Indeed, blast-induced mild TBI has been referred to as the signature injury of the conflicts in Iraq and Afghanistan.
Jane E. Risdall, David K. Menon
openaire   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source