Results 51 to 60 of about 1,402,310 (298)

Potential Applications and Ethical Considerations for Artificial Intelligence in Traumatic Brain Injury Management

Biomedicines
Artificial intelligence (AI) systems have emerged as promising tools for rapidly identifying patterns in large amounts of healthcare data to help guide clinical decision making, as well as to assist with medical education and the planning of research ...
Kryshawna Beard, Ashley M. Pennington, Amina K. Gauff, Kelsey Mitchell, Johanna Smith, Donald W. Marion   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation

Scientific Reports, 2021
Spinal cord injury (SCI) produces chronic, pro-inflammatory macrophage activation that impairs recovery. The mechanisms driving this chronic inflammation are not well understood.
Timothy J. Kopper, Bei Zhang, William M. Bailey, Kara E. Bethel, John C. Gensel   +4 more
doaj   +1 more source

Acceptance and commitment therapy delivered in a dyad after a severe traumatic brain injury: a feasibility study [PDF]

, 2018
Objective: There is a high prevalence of complex psychological distress after a traumatic brain injury but limited evidence of effective interventions.
Ciarrochi, Joseph V., Deane, Frank P., McLeod, Hamish J., Simpson, Grahame K., Whiting, Diane L.   +4 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

429 End user feedback on the Revised Department of Defense (DoD) Progressive Return to Activity (PRA): Primary Care for Acute Concussion Management Clinical Recommendation (CR)

Journal of Clinical and Translational Science
Objectives/Goals: The objectives of the study were to evaluate end-user feedback regarding usefulness and compliance with the revised DoD PRA-CR. The PRA-CR utilizes symptom-guided management strategies to advance service members with acute concussion ...
Jacques Arrieux, Jacques Arrieux, M. Victoria Ingram, Aaron Robinson, Seth Kiser, Rachel Lardieri, Keith Stuessi   +6 more
doaj   +1 more source

Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan

Biology, 2020
The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering, Justin A. Beller, Christopher M. Calulot, Diane M. Snow   +3 more
doaj   +1 more source

Links between traumatic brain injury and ballistic pressure waves originating in the thoracic cavity and extremities

, 2008
Identifying patients at risk of traumatic brain injury (TBI) is important because research suggests prophylactic treatments to reduce risk of long-term sequelae.
Alexander MP, Amy Courtney, Bruton C, Center for Disease Control and Prevention (CDC), Cernak I, Cernak I, Courtney M, Courtney M, Herrmann M, Krave U, Kushner DS, Kushner DS, Lowenstein DH, Margerison JH, Mayorga MA, Michael Courtney, Newgard K, Scott SG, Shaw NA, Stalnacke BM, Suneson A, Suneson A, Suneson A, Thompson HJ, Toth Z, Treib J, Trudeau DL, Vanderploeg RD, Vink R, Wang Q   +29 more
core   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source