Background and aims: Cerebral ischemia causes tissue oxidative damage and leads to cell death. Antioxidants can reduce the adverse effects of ischemia in the brain.
Kobra Mirahmadi+7 more
doaj +1 more source
Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [PDF]
The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min. After the end of ischemia and at different reperfusion times (2, 6, 12, 24, 48, 72, 96 h and 7 days), markers of lipid peroxidation, reduced and ...
arxiv
A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways). [PDF]
Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological ...
Applegate, Patricia M+5 more
core +2 more sources
Oxidative Stress in Brain Ischemia
Brain ischemia initiates a complex cascade of metabolic events, several of which involve the generation of nitrogen and oxygen free radicals. These free radicals and related reactive chemical species mediate much of damage that occurs after transient brain ischemia, and in the penumbral region of infarcts caused by permanent ischemia.
openaire +4 more sources
Actuated Hydrogel Platforms To Study Brain Cell Behavior
The complex and dynamic viscoelastic properties of the brain underpin neural plasticity and overall function. Actuating hydrogel platforms support mechanistic research to elucidate how brain cells respond to dynamic microenvironments. This study reviews the mechanobiology of the brain and its impact on brain function in health and disease and describes
Kirill E. Zhurenkov+3 more
wiley +1 more source
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils [PDF]
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils.
arxiv
Non‐Surgical, In‐Stent Membrane Bioelectronics for Long‐Term Intracranial Pressure Monitoring
This image shows a sequence of long‐term intracranial pressure monitoring using non‐surgical, in‐stent membrane bioelectronics. Abstract Traditional intracranial pressure (ICP) monitoring methods, using intraventricular catheters, face significant limitations, including high invasiveness, discrete data, calibration complexities, and drift issues, which
Jimin Lee+9 more
wiley +1 more source
Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats [PDF]
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury. The purpose of this study was to assess the neuroprotective effect and the neurological outcome after pyruvate administration in a model of ischemic stroke induced by permanent middle ...
arxiv
Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes [PDF]
Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury.
Barbeito, Osvaldo Luis+8 more
core +1 more source
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey+5 more
wiley +1 more source