Results 261 to 270 of about 1,655,573 (298)

The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance

Reviews in the Neurosciences, 2021
Abstract The glymphatic system and meningeal lymphatics have recently been characterized. Glymphatic system is a glia-dependent system of perivascular channels, and it plays an important role in the removal of interstitial metabolic waste products.
Galina Yankova, Olga Bogomyakova, Andrey Tulupov   +2 more
openaire   +2 more sources

Lymphatic Drainage System of the Brain: a New Player in Neuroscience

Journal of Evolutionary Biochemistry and Physiology, 2023
The lymphatic system not only plays an important role as a drainage eliminating metabolic wastes and toxins from tissues, but also represents an arena for the unfolding of immune response scenarios aimed at protecting the organism from bacteria and viruses.
O. V. Semyachkina-Glushkovskaya, D. E. Postnov, A. P. Khorovodov, N. A. Navolokin, Yu. G. G. Kurthz   +4 more
openaire   +1 more source

Role of meningeal lymphatic vessels in brain homeostasis

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Qing Tian, Chao-Yuan Ye, Chao‐Yuan Ye
exaly   +4 more sources

The role of the meningeal lymphatic in the brain clearing

Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 2019
Here in ex vivo (confocal imaging) and in vivo (optical coherent tomography) experiments on adult mice, we clearly demonstrate that the meningeal lymphatic drainage is an important mechanism for the brain clearing that might be also pathway for the brain clearing from metabolites and waste products that requests further detailed studies.
Maria Klimova, Alexander Dubrovsky, Erick Duarte Torres, Alexander Abdurashitov, Alexander Shirokov, Andrey Terskov, Alexander Khorovodov, Elena Sarantseva, Tatiana Iskra, Oxana Semyachkina-Glushkovskaya   +9 more
openaire   +1 more source

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

Immunology Today, 1992
This new view of the immunoreactivity of the normal brain is based on three key components. First, there is an active and highly-regulated communication between the brain and the central immune organs. Secondly, the connection from the brain to the draining nodes is much larger than previously appreciated.
H F, Cserr, P M, Knopf
openaire   +2 more sources

Our current understanding of the lymphatics of the brain and spinal cord

Clinical Anatomy, 2018
The lymphatic system, segregated from the blood vascular system, is an essential anatomical route along which interstitial fluid, solutes, lipids, immune cells, and cellular debris, are conveyed. However, the way these mechanisms operate within the cranial compartment is mostly unknown.
Dupont, Graham, Schmidt, Cameron, Yilmaz, Emre, Oskouian, Rod J., Macchi, Veronica, de Caro, Raffaele, Tubbs, R. Shane   +6 more
openaire   +3 more sources

Investigating the Lymphatic Drainage of the Brain: Essential Skills and Tools

2017
In this chapter we describe in detail the surgical and imaging techniques employed for the study of the anatomical routes of drainage of cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the brain. The types of tracers, sites of injection, and volumes injected are crucial.
Albargothy, Nazira J., Sharp, Matthew MacGregor, Gatherer, Maureen, Morris, Alan, Weller, Roy O., Hawkes, Cheryl, Carare, Roxana O.   +6 more
openaire   +3 more sources

Brain Lymphatics: Rediscovery and New Insights into Lymphatic Involvement in Diseases of Human Brains.

Lymphology
The brain's lymphatic system is comprised of a glymphatic-meningeal-cervical lymphatic vessel pathway. The study of its mechanism and pathophysiology in neurodegenerative disease has been one of the most exciting topics in basic and translational neuroscience of the last decade.
M J, Bartlett, R P, Erickson, E B, Hutchinson, R S, Witte, M H, Witte   +4 more
openaire   +1 more source

[Immunologic significance of lymphatic drainage of the brain].

Bulletin de l'Academie nationale de medecine, 1997
Despite the evidence for immunological reactions in the human CNS, in viral encephalitis and in multiple sclerosis, connections between the brain and the immune system are poorly understood. In rodents, tracers injected into the interstitial fluid of the brain drain to the cervical lymph nodes by perivascular pathways in the brain and nasal lymphatics.
R O, Weller, M J, Phillips, S, Kida, E T, Zhang   +3 more
openaire   +1 more source

Brain and other central nervous system tumor statistics, 2021

Ca-A Cancer Journal for Clinicians, 2021
Rebecca L. Siegel, Jill S. Barnholtz-Sloan, Carol Kruchko   +2 more
exaly