Results 261 to 270 of about 23,235 (301)

The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, Biomarker Imaging, and Precision Therapeutic Frontiers. [PDF]

Int J Mol Sci
Costea D, Dobrin N, Tataru CI, Toader C, Șerban M, Covache-Busuioc RA, Munteanu O, Diaconescu IB.   +7 more
europepmc   +1 more source

The Cerebral Lymphatic System: Function, Controversies, and Therapeutic Approaches for Central Nervous System Diseases. [PDF]

Cell Mol Neurobiol
Pan J, Fu Y, Yang P, Li W, Luo Z, Zhang A, Du J, Mei F, Liu F, Qi S, Bao Y.   +10 more
europepmc   +1 more source

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Lymphatic drainage of the brain

Experientia, 1968
In krassem Gegensatz zur heute herrschenden Auffassung spielt eine Lymphdrainage beim Flussigkeitskreislauf des Gehirns eine ausschlaggebende Rolle. Werden die zervikalen Lymphbahnen verschlossen, so entsteht eine lymphostatische Enzephalopathie, welche u.a.
M, Földi, B, Csillik, O T, Zoltán
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Acute brain vascular regeneration occurs via lymphatic transdifferentiation

Developmental Cell, 2021
Acute ischemic stroke damages the regional brain blood vessel (BV) network. Acute recovery of basic blood flows, which is carried out by the earliest regenerated BVs, are critical to improve clinical outcomes and minimize lethality. Although the late-regenerated BVs form via growing along the meninge-derived ingrown lymphatic vessels (iLVs), mechanisms
Jingying, Chen, Xiuhua, Li, Rui, Ni, Qi, Chen, Qifen, Yang, Jianbo, He, Lingfei, Luo   +6 more
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A (delayed) history of the brain lymphatic system

Nature Medicine, 2019
It has been only recently that scientists come to realize the existence of a lymphatic system within the central nervous system. However, an Italian anatomist had already found and described the system in fine detail over 200 years ago.
Stefano Sandrone, Daniel Moreno-Zambrano, Jonathan Kipnis, Jan van Gijn   +3 more
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Brain drains: new insights into brain clearance pathways from lymphatic biology

Journal of Molecular Medicine, 2018
The lymphatic vasculature act as the drainage system for most of our tissues and organs, clearing interstitial fluid and waste and returning them to the blood circulation. This is not the case for the central nervous system (CNS), which is devoid of parenchymal lymphatic vessels.
Bower, Neil I., Hogan, Benjamin M.
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Therapeutic Delivery to the Brain via the Lymphatic Vasculature

Nano Letters, 2020
Targeted delivery of therapeutics to disease sites has been one of the biggest challenges in medicine, as it determines the treatment efficacy of virtually all chemical and biological drugs. Furthermore, it is particularly difficult to achieve for diseases in the brain because of an additional barrier compared to other organs, the blood-brain barrier ...
Pengfei Zhao, Zhicheng Le, Lixin Liu, Yongming Chen   +3 more
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VEGFC-Mediated Lymphatic Drainage Increases Brain Tumor Immunogenicity

Cancer Discovery, 2020
Abstract A VEGFC-expressing mRNA construct improved immunotherapy response in mouse models of glioblastoma.
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The Brain and the Lymphatic System

2013
The brain lacks a local lymphatic system, primarily due to the closed environment of the skull which sets strict requirements for control of fluid balance and intracranial pressure. Proper fluid and pressure balance are maintained in the brain through the unique systems of cerebrospinal and interstitial fluid as well as a tight coupling between these ...
Mark E. Wagshul, Miles Johnston
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Meningeal lymphatic flow slows after mild traumatic brain injury

Nature Reviews Neurology, 2020
Bolte, A. C. et al. Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat. Commun. 11, 4524 (2020) Article Google Scholar Wardlaw, J. M. et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat. Rev. Neurol. 16, 137–153 (2020) Article Google Scholar Download references Nature Reviews Neurology Sarah
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