Results 21 to 30 of about 193,384 (260)

Outcomes of brain metastasis in high-grade bone and soft tissue sarcoma: An analysis of clinicopathological characteristics and survival data

Rare Tumors, 2021
Brain metastases in sarcoma are exceedingly rare, with few published series documenting ranges from 1% to 8%. This study investigated the outcomes of sarcoma patients with brain metastases using a population-based analysis.
Charles A Gusho, Alan T Blank, Marta Batus   +2 more
doaj   +1 more source

Blood–Brain Barrier, Cell Junctions, and Tumor Microenvironment in Brain Metastases, the Biological Prospects and Dilemma in Therapies

Frontiers in Cell and Developmental Biology, 2021
Brain metastasis is the most commonly seen brain malignancy, frequently originating from lung cancer, breast cancer, and melanoma. Brain tumor has its unique cell types, anatomical structures, metabolic constraints, and immune environment, which namely ...
Zhiyuan Guan, Hongyu Lan, Xin Cai, Yichi Zhang, Annan Liang, Jin Li   +5 more
doaj   +1 more source

Incidence of HER2-expressing brain metastases in patients with HER2-null breast cancer: a matched case analysis

npj Breast Cancer, 2023
The HER2-directed antibody-drug conjugate trastuzumab deruxtecan is active against lower levels of HER2 expression than prior-generation therapies. The rate of HER2 expression in brain metastases among patients with initially HER2-null breast cancer is ...
Nelson S. Moss, Jolene M. Singh, Anne S. Reiner, Joshua Z. Drago, Shanu Modi, Andrew D. Seidman, Sarat Chandarlapaty, Dara S. Ross   +7 more
doaj   +1 more source

Frequency of metastases within the hypothalamic–pituitary area and the associated high-risk factors in patients with brain metastases

Frontiers in Neurology, 2023
ObjectiveBrain radiotherapy often results in impairment of hypothalamic–pituitary (HT-P) function, which in turn causes secretory dysfunction of related hormones.
Peng Xie, Huiling Hu, Xiong Cao, Ning Lan, Huanyu Zhang, Ruifeng Yan, Peng Yue, Wenteng Hu, Hui Qiao, Hui Qiao   +9 more
doaj   +1 more source

Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis

Cell Reports, 2019
Summary: Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance.
Hila Doron, Malak Amer, Nour Ershaid, Raquel Blazquez, Ophir Shani, Tzlil Gener Lahav, Noam Cohen, Omer Adler, Zahi Hakim, Sabina Pozzi, Anna Scomparin, Jonathan Cohen, Muhammad Yassin, Lea Monteran, Rachel Grossman, Galia Tsarfaty, Chen Luxenburg, Ronit Satchi-Fainaro, Tobias Pukrop, Neta Erez   +19 more
doaj   +1 more source

The Predictive Value of Peripheral Immune Cell Counts for the Presence of Brain Metastases in Stage IV Non-Small-Cell Lung Cancer (NSCLC)

Avicenna Journal of Medicine, 2022
Background High neutrophil–lymphocyte ratio (NLR) is associated with poor survival in lung cancer. This study evaluates whether NLR is associated with baseline brain metastasis in stage IV non-small cell lung cancer (NSCLC).
I Abuelbeh, O Abu-Shawer, M Abu-Shawer, M Alkderat, M Safi, A Alwazani, A Alkhatib, B Abu-Hussain, M Aladawi, S Ismail, T Altamimi, Taher Abu Hejleh   +11 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Early detection of brain metastases and appropriate local therapy followed by systemic chemotherapy may improve the prognosis of gastric cancer

Scientific Reports, 2023
Brain metastases develop in 0.5–0.7% of patients with gastric/gastroesophageal junction (G/GEJ) cancer. Although rare, brain metastasis is often identified when the patient is already symptomatic; hence prognosis is poor.
Yasunobu Ishizuka, Takeshi Omori, Naoki Shinno, Masaaki Yamamoto, Hisashi Hara, Tomoyuki Otsuka, Minako Nishio, Naohiro Nishida, Fumie Fujisawa, Naotoshi Sugimoto, Toshinari Yagi, Masahiro Goto, Hiroki Nishikawa, Toshihiro Kudo   +13 more
doaj   +1 more source

Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients.

PLoS ONE, 2014
BackgroundBrain metastasis is a major complication of breast cancer. This study aimed to analyze the effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients.Patients and methodsWe identified subtypes of ...
Man-Hsin Hung, Chun-Yu Liu, Cheng-Ying Shiau, Chin-Yi Hsu, Yi-Fang Tsai, Yu-Ling Wang, Ling-Chen Tai, Kuang-Liang King, Ta-Chung Chao, Jen-Hwey Chiu, Cheng-Hsi Su, Su-Shun Lo, Cheng-Hwai Tzeng, Yi-Ming Shyr, Ling-Ming Tseng   +14 more
doaj   +1 more source