Results 31 to 40 of about 2,048,757 (259)

Experimental modeling and novel therapeutic strategies in melanoma brain metastasis [PDF]

, 2015
Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find new therapeutic approaches.
Sundstrøm, Terje
core   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology
Brain metastasis is increasingly understood as a disease of reciprocal adaptation between metastatic cells and the brain microenvironment. Among host cells, astrocytes have emerged as central regulators of metastatic colonization, survival, immune ...
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Incidence of HER2-expressing brain metastases in patients with HER2-null breast cancer: a matched case analysis

npj Breast Cancer, 2023
The HER2-directed antibody-drug conjugate trastuzumab deruxtecan is active against lower levels of HER2 expression than prior-generation therapies. The rate of HER2 expression in brain metastases among patients with initially HER2-null breast cancer is ...
Nelson S. Moss, Jolene M. Singh, Anne S. Reiner, Joshua Z. Drago, Shanu Modi, Andrew D. Seidman, Sarat Chandarlapaty, Dara S. Ross   +7 more
doaj   +1 more source

The Predictive Value of Peripheral Immune Cell Counts for the Presence of Brain Metastases in Stage IV Non-Small-Cell Lung Cancer (NSCLC)

Avicenna Journal of Medicine, 2022
Background High neutrophil–lymphocyte ratio (NLR) is associated with poor survival in lung cancer. This study evaluates whether NLR is associated with baseline brain metastasis in stage IV non-small cell lung cancer (NSCLC).
I Abuelbeh, O Abu-Shawer, M Abu-Shawer, M Alkderat, M Safi, A Alwazani, A Alkhatib, B Abu-Hussain, M Aladawi, S Ismail, T Altamimi, Taher Abu Hejleh   +11 more
doaj   +1 more source

BraMARS: An Interpretable Histopathology-Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited-Stage SCLC. [PDF]

Adv Sci (Weinh)
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Yang Z, Wang T, Liu S, Zhang Z, Zhang Y, Yang F, Yu B, Gao S, Chen Y, Yang L, Zhou M.   +10 more
europepmc   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients.

PLoS ONE, 2014
BackgroundBrain metastasis is a major complication of breast cancer. This study aimed to analyze the effect of age and biological subtype on the risk and timing of brain metastasis in breast cancer patients.Patients and methodsWe identified subtypes of ...
Man-Hsin Hung, Chun-Yu Liu, Cheng-Ying Shiau, Chin-Yi Hsu, Yi-Fang Tsai, Yu-Ling Wang, Ling-Chen Tai, Kuang-Liang King, Ta-Chung Chao, Jen-Hwey Chiu, Cheng-Hsi Su, Su-Shun Lo, Cheng-Hwai Tzeng, Yi-Ming Shyr, Ling-Ming Tseng   +14 more
doaj   +1 more source

ICOS-ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis. [PDF]

Adv Sci (Weinh)
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Kuo RC, Verma R, Nagy SC, Kalita M, Aubert S, Ballesteros-Álvarez J, Almeida PM, Vogel H, Alam IS, Lim M, James ML.   +10 more
europepmc   +2 more sources