Results 31 to 40 of about 193,384 (260)

Small extracellular vesicles in breast cancer brain metastasis and the prospect of clinical application

Frontiers in Bioengineering and Biotechnology, 2023
Extracellular vesicles (EVs) are nanoscale extracellular particles that have received widespread scientific attention for carrying a variety of biomolecules such as nucleic acids and proteins and participating in the process of intercellular information ...
Tingli Luo, Yue Kang, Yushi Liu, Jingyue Li, Jianyi Li   +4 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Genomic and immune profiling of breast cancer brain metastases

Acta Neuropathologica Communications
Background Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence.
Amanda E. D. Van Swearingen, Marissa R. Lee, Layne W. Rogers, Alexander B. Sibley, Pixu Shi, Xiaodi Qin, Michael Goodin, Katelyn Seale, Kouros Owzar, Carey K. Anders   +9 more
doaj   +1 more source

The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage

Brain Hemorrhages
Blood-brain barrier (BBB) damage is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of brain edema and the inflammatory response post-ICH. Cerebral immune cells (CICs), including microglia, pericytes, and
Yihui Wang, Wencao Liu, Jianing Zhang, Panpan Geng, Xinchun Jin   +4 more
doaj   +1 more source

Emerging findings into molecular mechanism of brain metastasis

Cancer Medicine, 2018
Brain metastasis is an important cause of morbidity and mortality in cancer patients. Hence, the need to develop improved therapies to prevent and treat metastasis to the brain is becoming urgent.
Wenting Ni, Wenxing Chen, Yin Lu
doaj   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Analysis of Survival Predictors in Patients with Lung Cancer and Brain Metastases

Chinese Journal of Lung Cancer, 2015
Background and objective The prognosis for patients with lung cancer and brain metastases remains poor, with approximately 6 months of survival, despite active measures after treatment.
Shaohua CUI, Hao BAI, Lili DONG, Yizhuo ZHAO, Aiqin GU, Wei ZHANG, Yuqing LOU, Liyan JIANG   +7 more
doaj   +1 more source

Insights into brain metastasis: Recent advances in circulating tumor cell research

Cancer Reports, 2022
Background How tumor cells disseminate to brain and establish brain metastasis remains partly an unsolved problem. This devastating complication of many cancers is initiated by a rare subset of the circulating tumor cells (CTCs) shed into the blood ...
Remi Klotz, Min Yu
doaj   +1 more source

Isolated progression of miliary brain metastasis in a patient with stable lung adenocarcinoma successfully treated with whole-brain radiotherapy: A case report

eNeurologicalSci, 2021
Miliary brain metastasis is a rare form of metastasis commonly associated with advanced stages of cancer. In this article, we report a case of a 38-year-old male with solitary progression of miliary brain metastasis originating from stage 4 EML-ALK ...
Satomi Hiya, Satoru Fujiwara, Atsushi Nakagawa, Yuki Sato, Yoshihiro Omura, Shigeo Hara, Nobuo Kohara, Michi Kawamoto   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source