Results 51 to 60 of about 2,048,757 (259)

Analysis of Survival Predictors in Patients with Lung Cancer and Brain Metastases

Chinese Journal of Lung Cancer, 2015
Background and objective The prognosis for patients with lung cancer and brain metastases remains poor, with approximately 6 months of survival, despite active measures after treatment.
Shaohua CUI, Hao BAI, Lili DONG, Yizhuo ZHAO, Aiqin GU, Wei ZHANG, Yuqing LOU, Liyan JIANG   +7 more
doaj   +1 more source

Small extracellular vesicles in breast cancer brain metastasis and the prospect of clinical application

Frontiers in Bioengineering and Biotechnology, 2023
Extracellular vesicles (EVs) are nanoscale extracellular particles that have received widespread scientific attention for carrying a variety of biomolecules such as nucleic acids and proteins and participating in the process of intercellular information ...
Tingli Luo, Yue Kang, Yushi Liu, Jingyue Li, Jianyi Li   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

STAT3-mediated astrocyte reactivity associated with brain metastasis contributes to neurovascular dysfunction [PDF]

, 2020
Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphological changes in response to brain metastasis, switching to a reactive phenotype which has the ...
Serres, Sébastien, Larkin, James R, Sibson, Nicola R, Economopoulos, Vasiliki, Escartin, C., Sibson, Nicola R., Sarmiento Soto, M., Escartin, Carole, Larkin, J.R., Serres, S., Scott, H., Sibson, N.R., Larkin, James, Larkin, James R., Khrapitchev, Alexandre, Bonvento, G., Sarmiento Soto, Manuel, Maczka, M., Bonvento, , Gilles, Khrapitchev, A.A., Bonvento, Gilles, Serres, S�bastien, Martin, Chris, Economopoulos, V., Khrapitchev, Alexandre A, Martin, C., Sibson, Nicola, Khrapitchev, Alexandre A., Scott, Helen, Maczka, Melissa   +29 more
core   +1 more source

The progress of treatment for brain metastases of triple-negative breast cancer [PDF]

Zhongguo aizheng zazhi
Breast cancer has been the second most common solid tumor that metastasizes to the central nervous system after lung cancer. Triple-negative breast cancer (TNBC) has an earlier occurrence and high incidence of brain metastasis with its associated poor ...
CAO Xiaoshan, YANG Beibei, CONG Binbin, LIU Hong
doaj   +3 more sources

Isolated progression of miliary brain metastasis in a patient with stable lung adenocarcinoma successfully treated with whole-brain radiotherapy: A case report

eNeurologicalSci, 2021
Miliary brain metastasis is a rare form of metastasis commonly associated with advanced stages of cancer. In this article, we report a case of a 38-year-old male with solitary progression of miliary brain metastasis originating from stage 4 EML-ALK ...
Satomi Hiya, Satoru Fujiwara, Atsushi Nakagawa, Yuki Sato, Yoshihiro Omura, Shigeo Hara, Nobuo Kohara, Michi Kawamoto   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Trans-BBB peptides for targeting brain metastasis

, 2022
Cancer is a heterogeneous and still not well-understood disease, being one of the most significant health problems worldwide. Among women, the most common cancer type is breast cancer. It accounts for 1 in 4 cancer cases and 1 in 6 cancer deaths.
Cavaco, Marco
core  

Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies

BMC Cancer, 2018
Background Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4–5 months. Since 2011, the overall survival of patients with stage IV melanoma has been significantly improved with the advent of new ...
Elham Vosoughi, Jee Min Lee, James R. Miller, Mehdi Nosrati, David R. Minor, Roy Abendroth, John W. Lee, Brian T. Andrews, Lewis Z. Leng, Max Wu, Stanley P. Leong, Mohammed Kashani-Sabet, Kevin B. Kim   +12 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source