Results 61 to 70 of about 2,048,757 (259)

Insights into brain metastasis: Recent advances in circulating tumor cell research

Cancer Reports, 2022
Background How tumor cells disseminate to brain and establish brain metastasis remains partly an unsolved problem. This devastating complication of many cancers is initiated by a rare subset of the circulating tumor cells (CTCs) shed into the blood ...
Remi Klotz, Min Yu
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Selective permeabilisation of the blood-brain barrier during brain metastasis via TNFR1 [PDF]

, 2019
The presence of an intact, impermeable blood-brain barrier (BBB) during the early stages of metastatic colonisation significantly limits early detection and effective treatment of brain metastasis.
Karali, Christina Simoglou
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinomaCentral MessagePerspective

JTCVS Open
Objective: To identify clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinoma (LUAD) and to evaluate survival after brain metastasis.
Elizabeth G. Dunne, MD, Cameron N. Fick, MD, Brooke Mastrogiacomo, MS, Kay See Tan, PhD, Nicolas Toumbacaris, MSPH, Stijn Vanstraelen, MD, Gaetano Rocco, MD, Jaime E. Chaft, MD, Puneeth Iyengar, MD, Daniel Gomez, MD, Prasad S. Adusumilli, MD, Bernard J. Park, MD, James M. Isbell, MD, Matthew J. Bott, MD, Smita Sihag, MD, Daniela Molena, MD, James Huang, MD, David R. Jones, MD   +17 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases

, 2022
SIMPLE SUMMARY: Brain metastases are increasingly common in cancer patients and hurt survival and quality of life. Therefore, efforts are increasingly devoted to research into brain metastases and discovering new diagnostic approaches and therapeutic ...
Tomas Kazda, Jiri Sana, Kazda, Tomas, Martin Smrcka, Siegl, Frantisek, Roskova, Ivana, Marek Vecera, Slaby, Ondrej, Frantisek Siegl, Ivana Roskova, Vecera, Marek, Radim Jancalek, Ondrej Slaby, Smrcka, Martin, Jancalek, Radim, Sana, Jiri   +15 more
core   +1 more source

Brain metastases from prostate cancer: A single-center experience

Urology Research and Practice, 2019
Objective: Metastases from prostate cancer to the brain are very unusual and very few case series have been reported in the literature. Present study was performed to assess the proportion of brain metastasis from prostate cancer among other brain ...
Gül Kanyılmaz, Meryem Aktan, Berrin Benli Yavuz, Mehmet Koç   +3 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source