Results 81 to 90 of about 2,048,757 (259)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Multiple Meningocerebral Metastasis and Extensive Skull Metastasis from Squamous Cell Carcinoma of Esophagus: A Case Report and Review of Literature. [PDF]

, 2016
Esophageal carcinoma rarely metastasizes to the brain. Although some studies have mentioned esoph ageal cancer with solitary brain metastasis or with meningocerebral metastasis or with skull metastasis, multiple meningocerebral metastasis and extensive ...
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core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Bieneck, S, Muñoz, N, Quest, AF, Bennett, DC, Silva, V, Sviderskayae, Elena V., Lobos González, Lorena, Muñoz, Nicolás, Fernandez, JG, Silva, Verónica, Hossain, Mehnaz, Bennett, Dorothy C., Fernández Ruiz, Jaime Gonzalo, Quest, Andrew F. G., Burzio, V, Leyton, L, Quest, Andrew F.G., Lobos-Gonzalez, L, Bieneck, Simone, Sviderskaya, EV, Burzioc, Verónica, Aguilar Guzmán, Lorena, Hossain, M, Aguilar Guzmán, Lorena Andrea, Aguilar-Guzmán, L, Leyton Campos, Lisette   +25 more
core   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Synaptic proximity enables NMDAR signalling to promote brain metastasis [PDF]

, 2019
Metastasis-the disseminated growth of tumours in distant organs-underlies cancer mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and is prevalent in the aggressive basal-like subtype, but is also found at varying ...
Robinson, Hugh P. C., Giovanni Ciriello, Zhang, Peng, José A. Galván, Zlobec, Inti, Michael, Iacovos P., Iacovos P. Michael, Douglas Hanahan, Brian D. McCabe, Peng Zhang, Graham Knott, Inti Zlobec, Zeng, Qiqun, McCabe, Brian D., Galvan, Jose A., Saghafinia, Sadegh, Ciriello, Giovanni, Sadegh Saghafinia, Knott, Graham, Hanahan, Douglas, Qiqun Zeng, Wei Jiao, Hugh P. C. Robinson, Jiao, Wei   +23 more
core   +3 more sources

Brain metastasis-related microRNAs in patients with advanced breast cancer.

PLoS ONE, 2019
Brain metastasis is a major distant metastasis occurring in patients with advanced breast cancer, and is associated with poor prognosis. MicroRNAs (miRNAs) have a strong influence on various oncological functions and have been reported as potential ...
Jun Sato, Akihiko Shimomura, Junpei Kawauchi, Juntaro Matsuzaki, Yusuke Yamamoto, Satoko Takizawa, Hiromi Sakamoto, Makoto Ohno, Yoshitaka Narita, Takahiro Ochiya, Kenji Tamura   +10 more
doaj   +1 more source

Autonomous Navigation of Pollen‐Inspired Magnetic Microrobots for Biomedical Applications

Advanced Robotics Research, EarlyView.
A sunflower pollen‐inspired magnetic microrobot enables controlled rolling navigation in vessel‐like environments. Its open geometry reduces hydrodynamic drag, while vision‐based closed‐loop control, shortest‐path planning, and reinforcement learning support target‐reaching and maze navigation with microrobot‐scale accuracy, highlighting a route toward
Ali Anil Demircali, Abdurrahim Yilmaz, Meysam Keshavarz, Jinshi Zhao, Ara Darzi, Eric Yeatman, Burak Temelkuran   +6 more
wiley   +1 more source

Characterizing the Natural History of Pediatric Brain Tumors Presenting with Metastasis

Background: The natural history of pediatric patients with metastasis of primary brain tumors within and outside the central nervous system is poorly understood, as too are possible clinical correlates with outcome. Correspondingly, the aim of this study
Victor M. Lu, Toba N. Niazi
core   +1 more source

Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications

, 2022
Extracellular vesicles (EVs) are heterogeneous membrane-encapsulated vesicles released by most cells. They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs).
Liu, Yu Xuan, Yu Xuan Liu, Zhaowu Ma, Xiao-Ping Tan, Cai-Hua Zhang, Qian Jiang, Tan, Xiao-Ping, Li, Du, Lingzhi Wang, Xu, Yan, Zhang, Cai-Hua, Li, Zhi-Yuan, Wang, Lingzhi, Ma, Zhaowu, Zhi-Yuan Li, Jiang, Qian, Du Li, Yan Xu   +17 more
core   +1 more source