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Nature Reviews Disease Primers, 2019 An estimated 20% of all patients with cancer will develop brain metastases, with the majority of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma or renal cell carcinoma. Brain metastases are thought to occur via seeding of circulating tumour cells into the brain microvasculature; within this unique ...
Robert C Rennert +2 more
exaly +8 more sources
Epidemiology of brain metastases and leptomeningeal disease
Neuro-Oncology, 2021 Brain metastases affect a significant percentage of patients with advanced extracranial malignancies. Yet, the incidence of brain metastases remains poorly described, largely due to limitations of population-based registries, a lack of mandated reporting
Nayan Lamba +2 more
exaly +2 more sources
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
Nature Reviews Cancer, 2019 For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel wall to reach cancer cells in adequate quantities, and it must overcome the resistance conferred by the local microenvironment around cancer cells.
Costas D Arvanitis, Gino B Ferraro
exaly +2 more sources
PD-1 inhibitor combined with chemoradiotherapy in two cases of ovarian cancer brain metastases: a case report [PDF]
Frontiers in OncologyBackgroundTo investigate the clinical efficacy and potential mechanisms of immune checkpoint inhibitors (PD-1 inhibitors) combined with chemotherapy and targeted therapy in ovarian cancer patients with brain metastases, and to analyze the relationship ...
Yanke Li +4 more
doaj +2 more sources
Targeting B7-H3 in patients with metastatic triple-negative breast cancer and brain metastases: an opportunity to “revive” immunotherapy as a treatment strategy? [PDF]
Journal for ImmunoTherapy of CancerApproximately one-third of patients with metastatic triple-negative breast cancer (TNBC) develop brain metastases during their lifetime. Notably, up to 90% of TNBC brain metastases express B7-H3, a molecule that contributes to an immunosuppressive ...
Jane Bayani +6 more
doaj +2 more sources
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Journal of Clinical Oncology, 2021 PURPOSE To provide guidance to clinicians regarding therapy for patients with brain metastases from solid tumors. METHODS ASCO convened an Expert Panel and conducted a systematic review of the literature.
M. Vogelbaum +21 more
semanticscholar +1 more source
Nature Medicine, 2022 Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. We conducted the prospective, open-label, single-arm, phase 2 TUXEDO-1 trial.
R. Bartsch +22 more
semanticscholar +1 more source
Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline.
Practical Radiation Oncology, 2022 PURPOSE This guideline provides updated evidence-based recommendations addressing recent developments in the management of patients with brain metastases, including advanced radiation therapy techniques such as stereotactic radiosurgery (SRS) and ...
V. Gondi +19 more
semanticscholar +1 more source
Microenvironment and the progress of immunotherapy in clinical practice of NSCLC brain metastasis
Frontiers in Oncology, 2023 One of the most frequent distant metastases of lung cancer occurs in the brain. The average natural survival duration for patients with lung cancer who have brain metastases is about 1 to 2 months. Knowledge about brain metastases is currently restricted
Mengqing Xie, Chunxia Su
doaj +1 more source
The effectiveness of chemotherapy in breast cancer patients with brain metastases [PDF]
Korean Journal of Clinical Oncology, 2014 Purpose: Treatments of brain metastases in breast cancer include whole brain radiotherapy, surgery, stereotactic radiosurgery, and systemic chemotherapy.
Won Cheol Chang +5 more
doaj +1 more source