Results 41 to 50 of about 2,926,291 (344)

Characterization of the immune microenvironment in brain metastases from different solid tumors

Cancer Medicine, 2020
Background Brain metastases are one of the most common intracranial neoplasms. Increasing evidence have indicated that systemic immunotherapy may provide long‐term benefits for brain metastases.
Jinling Jiang, Lihong Wu, Fei Yuan, Jun Ji, Xiaojing Lin, Wanning Yang, Junwei Wu, Min Shi, Hui Yang, Yanna Ma, Xue Song, Zhenggang Zhu, Henghui Zhang, Jun Zhang   +13 more
doaj   +1 more source

Integrating multimodal management and molecular profiling in a patient with BRAF V600E–positive melanoma and brain metastases [PDF]

Ca-A Cancer Journal for Clinicians
David Gritsch, Kevin S Oh, Gavin P Dunn
exaly   +2 more sources

Survival in Patients With Brain Metastases: Summary Report on the Updated Diagnosis-Specific Graded Prognostic Assessment and Definition of the Eligibility Quotient.

Journal of Clinical Oncology, 2020
PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials for fear that poor survival could mask the benefit of otherwise promising treatments.
P. Sperduto, S. Mesko, Jing Li, D. Cagney, A. Aizer, N. Lin, E. Nesbit, T. Kruser, J. Chan, S. Braunstein, Jessica Lee, J. Kirkpatrick, W. Breen, P. Brown, D. Shi, H. Shih, H. Soliman, A. Sahgal, R. Shanley, W. Sperduto, E. Lou, A. Everett, D. Boggs, L. Masucci, D. Roberge, J. Remick, K. Plichta, J. Buatti, Supriya K. Jain, L. Gaspar, Cheng-Chia Wu, T. Wang, J. Bryant, M. Chuong, Y. An, V. Chiang, Toshimichi Nakano, H. Aoyama, M. Mehta   +38 more
semanticscholar   +1 more source

Roles of Neutrophils in Glioma and Brain Metastases

Frontiers in Immunology, 2021
Neutrophils, which are the most abundant circulating leukocytes in humans, are the first line of defense against bacterial and fungal infections. Recent studies have reported the role and importance of neutrophils in cancers.
Ya-Jui Lin, Kuo-Chen Wei, Pin-Yuan Chen, M. Lim, T. Hwang   +4 more
semanticscholar   +1 more source

Small vessel ischemic disease of the brain and brain metastases in lung cancer patients. [PDF]

PLoS ONE, 2009
Brain metastases occur commonly in patients with lung cancer. Small vessel ischemic disease is frequently found when imaging the brain to detect metastases.
Peter J Mazzone, Nicola Marchi, Vince Fazio, J Michael Taylor, Thomas Masaryk, Luke Bury, Tarek Mekhail, Damir Janigro   +7 more
doaj   +1 more source

Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites

Journal for ImmunoTherapy of Cancer, 2022
Background The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorable ...
John F Thompson, Serigne Lo, Ines Pires da Silva, Georgina V Long, Richard A Scolyer, Andrew J Spillane, Robert V Rawson, Tasnia Ahmed, Jordan W Conway, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Grace Heloise Attrill, Tuba N Gide, Robyn P M Saw, Kerwin F Shannon, Brindha Shivalingam, Alexander Maxwell Menzies   +17 more
doaj   +1 more source

Outcomes With Pembrolizumab Monotherapy in Patients With Programmed Death-Ligand 1–Positive NSCLC With Brain Metastases: Pooled Analysis of KEYNOTE-001, 010, 024, and 042

JTO Clinical and Research Reports, 2021
Introduction We retrospectively evaluated outcomes in patients with programmed death-ligand 1 (PD-L1)–positive non–small-cell lung cancer (NSCLC) to determine whether baseline (i.e., at study enrollment) brain metastases were associated with the efficacy
A. Mansfield, R. Herbst, G. de Castro, R. Hui, N. Peled, Dong-Wan Kim, S. Novello, M. Satouchi, Yi-long Wu, E. Garon, M. Reck, A. Robinson, A. Samkari, B. Piperdi, V. Ebiana, Jianxin Lin, T. Mok   +16 more
semanticscholar   +1 more source

Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model. [PDF]

PLoS ONE, 2013
Longitudinal MRI was applied to monitor intracranial initiation and development of brain metastases and assess tumor vascular volume and permeability in a mouse model of breast cancer brain metastases.
Heling Zhou, Min Chen, Dawen Zhao
doaj   +1 more source

Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma.

JAMA Oncology, 2021
Importance Patients with brain metastases from renal cell carcinoma (RCC) have been underrepresented in clinical trials, and effective systemic therapy is lacking.
L. Hirsch, N. Martínez Chanzá, S. Farah, W. Xie, R. Flippot, D. Braun, N. Rathi, J. Thouvenin, K. Collier, E. Seront, G. de Velasco, H. Dzimitrowicz, B. Beuselinck, Wenxin Xu, I. Bowman, E. Lam, Bashar Abuqayas, M. Bilen, Andreas Varkaris, Y. Zakharia, M. Harrison, A. Mortazavi, P. Barthélémy, N. Agarwal, R. McKay, P. Brastianos, K. Krajewski, L. Albiges, L. Harshman, T. Choueiri   +29 more
semanticscholar   +1 more source

Brain and spinal cord metastases with seminoma: A case report

IJU Case Reports, 2022
Introduction Brain and spinal cord metastases from testicular cancer occur rarely, and metastases with seminoma are extremely rare. Case presentation A 42‐year‐old man who was diagnosed with seminoma and multiple metastases underwent first‐line and ...
Tetsuya Yumioka, Shuichi Morizane, Karen Makishima, Tadashi Adachi, Emika Moriyasu, Hideto Iwamoto, Katsuya Hikita, Masashi Honda, Yoshihisa Umekita, Atsushi Takenaka   +9 more
doaj   +1 more source